Recent advances in multifunctional fluorescent probes for viscosity and analytes

Graphene-based electrochemical sensors for antibiotic detection in water, food and soil: A scientometric analysis in CiteSpace (2011-2021).

Recent progress on small molecule-based fluorescent imaging probes for hypochlorous acid (HOCl)/Hypochlorite (OCl−)

Antibiotics can accumulate through food metabolism in the human body which may have a significant effect on human safety and health. It is therefore highly beneficial to establish easy and sensitive approaches for rapid assessment of antibiotic amounts. In the development of next-generation biosensors, nanomaterials (NMs) with outstanding thermal, mechanical, optical, and electrical properties have been identified as one of the most hopeful materials for opening new gates. This study discusses the latest developments in the identification of antibiotics by nanomaterial-constructed biosensors. The construction of biosensors for electrochemical signal-transducing mechanisms has been utilized in various types of nanomaterials, including quantum dots (QDs), metal-organic frameworks (MOFs), magnetic nanoparticles (NPs), metal nanomaterials, and carbon nanomaterials. To provide an outline for future study directions, the existing problems and future opportunities in this area are also included. The current review, therefore, summarizes an in-depth assessment of the nanostructured electrochemical sensing method for residues of antibiotics in different systems.

The Application of Nanomaterials for the Electrochemical Detection of Antibiotics: A Review

Safety and quality are key issues for the food industry. Consequently, there is growing demand to preserve the food chain and products against substances toxic, harmful to human health, such as contaminants, allergens, toxins, or pathogens. For this reason, it is mandatory to develop highly sensitive, reliable, rapid, and cost-effective sensing systems/devices, such as electrochemical sensors/biosensors. Generally, conventional techniques are limited by long analyses, expensive and complex procedures, and skilled personnel. Therefore, developing performant electrochemical biosensors can significantly support the screening of food chains and products. Here, we report some of the recent developments in this area and analyze the contributions produced by electrochemical biosensors in food screening and their challenges.

https://www.mdpi.com/1420-3049/26/10/2940/pdf

Electrochemical Biosensors in Food Safety: Challenges and Perspectives.

In recent years, the abuse of antibiotics has led to the pollution of soil and water environment, not only poultry husbandry and food manufacturing will be influenced to different degree, but also the human body will produce antibody. The detection of antibiotic content in production and life is imperative. In this review, we provide comprehensive information about chemical sensors and biosensors for antibiotic detection. We classify the currently reported antibiotic detection technologies into chromatography, mass spectrometry, capillary electrophoresis, optical detection, and electrochemistry, introduce some representative examples for each technology, and conclude the advantages and limitations. In particular, the optical and electrochemical methods based on nanomaterials are discussed and evaluated in detail. In addition, the latest research in the detection of antibiotics by photosensitive materials is discussed. Finally, we summarize the pros and cons of various antibiotic detection methods and present a discussion and outlook on the expansion of cross-scientific areas. The synthesis and application of optoelectronic nanomaterials and aptamer screening are discussed and prospected, and the future trends and potential impact of biosensors in antibiotic detection are outlined.Graphical abstract.

https://link.springer.com/content/pdf/10.1007/s00604-020-04671-3.pdf

Recent development of antibiotic detection in food and environment: the combination of sensors and nanomaterials

This study describes the development, verification and practical application of an aptasensor for the fluorometric detection of kanamycin. Using the nucleic acid aptamer with FAM fluorescent group as the conjugate, using gold nanoparticles as the fluorescence dynamic quenching source, a fluorescence sensor was fabricated through the signal-on method for the micro-detection of kanamycin. The nucleic acid chimera is connected to the fluorophore, and the gold nanoparticles are used as the fluorescence dynamic quenching source under actual conditions. The detection limit of kanamycin is 0.1 pM, and the detection range is 0.1 pM to 0.1 μM. This biosensor works satisfactorily in complex samples with no impurities, which gives this method an obvious advantage over other analytical methods. In addition, the mechanism of action between gold nanoparticles/FAM–aptamer/kanamycin is discussed and studied in depth here. It provides a more thorough analysis and more application possibilities for fluorescence-aptamer biosensing.

/pdf/a-signal-on-fluorescent-aptasensor-based-on-gold-wppxqnzhml.pdf

A signal-on fluorescent aptasensor based on gold nanoparticles for kanamycin detection

The reasonable cellular redox equilibrium mediated by reactive oxygen species/reactive nitrogen species and antioxidants are pivotal importance for maintaining a variety of physiological processes, and disrupted redox equilibrium may derange the cellular components and eventually may lead to cell death, irreversible tissue destruction, and various diseases. In this paper, we develop a phenylseleno-functionalized reversible fluorescent probe Fluo-Se for monitoring the hypochlorous acid/cysteine redox couple in living cells. The advantages of the probe included: a) the synthetic procedure of the probe is very simple by one step reaction; b) the probe shows high sensitivity for HOCl and cysteine (the detection limit is 1.1 nM and 3.0 nM, respectively); c) the probe exhibits high reversibility to the hypochlorous acid/cysteine redox couple both in solutions and in the living cell by taking advantage of the Se atom-led excellent reversible conversions between Fluo-Se and its oxidized product. We think that Fluo-Se should be very useful for gauging the cellular redox status mediated by the hypochlorous acid/cysteine couple.

Facile functionalized fluorescein derivative as a reversible fluorescence probe for selective monitor of the redox cycle between hypochlorous acid and cysteine

Lijuan Liang

Papers

Recent development of antibiotic detection in food and environment: the combination of sensors and nanomaterials

A signal-on fluorescent aptasensor based on gold nanoparticles for kanamycin detection

Facile functionalized fluorescein derivative as a reversible fluorescence probe for selective monitor of the redox cycle between hypochlorous acid and cysteine

Highly selective turn-on fluorescent probe for hypochlorite and viscosity detection

A phenothiazine-based turn-on fluorescent probe for selective quantification of HClO in living cells