L
Lilian Afonso
Researcher at Oswaldo Cruz Foundation
Publications - 9
Citations - 441
Lilian Afonso is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Leishmania & Leishmania mexicana. The author has an hindex of 7, co-authored 9 publications receiving 411 citations. Previous affiliations of Lilian Afonso include Federal University of Bahia.
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Journal ArticleDOI
Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection
Fernanda O. Novais,Rômulo C. Santiago,André Báfica,Ricardo Khouri,Lilian Afonso,Valéria M. Borges,Cláudia Brodskyn,Manoel Barral-Netto,Aldina Barral,Camila I. de Oliveira +9 more
TL;DR: The results indicate that neutrophils play an important and previously unappreciated role in L. braziliensis infection, favoring the induction of a protective immune response.
Journal ArticleDOI
Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis
Lilian Afonso,Lilian Afonso,Valéria M. Borges,Heloísa Cruz,Heloísa Cruz,Flávia L. Ribeiro-Gomes,George A. DosReis,Alberto Noronha Dutra,Jorge Clarêncio,Camila I. de Oliveira,Aldina Barral,Aldina Barral,Manoel Barral-Netto,Manoel Barral-Netto,Cláudia Brodskyn,Cláudia Brodskyn +15 more
TL;DR: It is demonstrated that phagocytosis of these cells in an apoptotic or necrotic stage can influence the outcome of infection, driving either parasite survival or destruction.
Journal ArticleDOI
Lutzomyia longipalpis salivary gland homogenate impairs cytokine production and costimulatory molecule expression on human monocytes and dendritic cells.
Dirceu Costa,Dirceu Costa,Cecília Favali,Cecília Favali,Jorge Clarêncio,Lilian Afonso,Viviane Conceicao,José Carlos Miranda,Richard G. Titus,Jesus G. Valenzuela,Manoel Barral-Netto,Manoel Barral-Netto,Aldina Barral,Aldina Barral,Cláudia Brodskyn,Cláudia Brodskyn +15 more
TL;DR: Preincubating SGH with human sera containing anti-SGH-specific antibodies abolished the effects of SGH on cytokine production by LPS-stimulated monocytes and costimulatory molecules on monocytes, macrophages, and dendritic cells.
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Understanding the Mechanisms Controlling Leishmania amazonensis Infection In Vitro: The Role of LTB4 Derived From Human Neutrophils
Natalia Machado Tavares,Théo Araújo-Santos,Théo Araújo-Santos,Lilian Afonso,Paula Monalisa Nogueira,Ulisses Gazos Lopes,Rodrigo Pedro Soares,Patrícia T. Bozza,Christianne Bandeira-Melo,Valéria M. Borges,Cláudia Brodskyn,Cláudia Brodskyn,Cláudia Brodskyn +12 more
TL;DR: Using pharmacological inhibitors of leukotriene synthesis, this study shows that L. amazonensis or its lipophosphoglycan can induce neutrophil activation, degranulation, and LTB4 production, and reveals an L TB4-driven autocrine/paracrine regulatory effect.
Journal ArticleDOI
Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils
Deboraci B. Prates,Deboraci B. Prates,Théo Araújo-Santos,Théo Araújo-Santos,Nívea F. Luz,Nívea F. Luz,Bruno B. Andrade,Jaqueline França-Costa,Jaqueline França-Costa,Lilian Afonso,Lilian Afonso,Jorge Clarêncio,José Carlos Miranda,Patrícia T. Bozza,George A. DosReis,Cláudia Brodskyn,Manoel Barral-Netto,Manoel Barral-Netto,Valéria M. Borges,Aldina Barral,Aldina Barral +20 more
TL;DR: The hypothesis that vector salivary proteins trigger caspase‐dependent and FasL‐mediated apoptosis, thereby favoring Leishmania survival inside neutrophils, is supported, which may represent an important mechanism for the establishment of Leishmaniasis.