Lily E. Adams

TL;DR: A model in mouse using a species-adapted virus recapitulates features of SARS-CoV-2 infection and age-related disease pathogenesis in humans, and provides a model system for rapid evaluation of medical countermeasures against coronavirus disease 2019 (COVID-19).

TL;DR: This mouse-adapted SARS-CoV-2 model demonstrates age-related disease pathogenesis and supports the clinical use of IFN lambda-1a treatment in human COVID-19 infections and shows that clinical candidate interferon (IFN) lambda- 1a can potently inhibit SARS's replication in primary human airway epithelial cells in vitro and both prophylactic and therapeutic administration diminished replication in mice.

TL;DR: Zhou et al. as discussed by the authors investigated mRNA-vaccine-induced antibody responses against the reference strain, seven variants, and seasonal coronaviruses in 168 healthy individuals at three time points: before vaccination, after the first dose, and after the second dose.

TL;DR: Using genomewide CRISPR knockout screening, the placenta-associated 8 protein (PLAC8) is identified as an essential host factor for SADS-CoV infection, uncovering a novel antiviral target for CoV infection.

TL;DR: In this paper, the authors identify residue determinants that mediate coronavirus receptor usage and host range for application in SARS-CoV-2 and emerging Coronavirus animal model development.