L
Lin Mei
Researcher at Case Western Reserve University
Publications - 266
Citations - 18002
Lin Mei is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Neuromuscular junction & Agrin. The author has an hindex of 69, co-authored 245 publications receiving 15903 citations. Previous affiliations of Lin Mei include University of Arizona & Chinese Academy of Sciences.
Papers
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Journal ArticleDOI
The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein
Chao Shi,Xuan Huang,Bin Zhang,Dan Zhu,Huqiao Luo,Quqin Lu,Wen Cheng Xiong,Lin Mei,Shiwen Luo +8 more
TL;DR: It is shown that PABPN1 interacts with and is stabilized by heat shock protein 90 (HSP90) and a potential therapeutic application of the HSP90 inhibitor 17-AAG for the treatment of OPMD is suggested.
Book ChapterDOI
Morphological Analysis of Neuromuscular Junctions by Immunofluorescent Staining of Whole-Mount Mouse Diaphragms
Haitao Wu,Lin Mei +1 more
TL;DR: The immunofluorescent staining of whole-mount neonatal mouse diaphragms is described to study the morphological patterns of the neuromuscular junction by using of presynaptic neuronal marker-neurofilament and synaptophysin antibodies.
Journal ArticleDOI
Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.
Hua-Li Yu,Yun Peng,Yang Zhao,Yang Zhao,Yong-Sheng Lan,Yong-Sheng Lan,Bo Wang,Bo Wang,Lu Zhao,Lu Zhao,Lu Zhao,Dong Sun,Jin-Xiu Pan,Zhaoqi Dong,Lin Mei,Lin Mei,Yu-Qiang Ding,Xiaojuan Zhu,Wen Cheng Xiong,Wen Cheng Xiong +19 more
TL;DR: Netrin-1 increases Myosin X (Myo X) interaction with KIF13B, and thus promotes axonal delivery of Myo X and axon initiation and contralateral branching in developing cerebral neurons, revealing unrecognized functions and mechanisms underlying Netrin- 1 regulation of axon development.
Journal ArticleDOI
pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo
Lu Zhao,Yang Zhao,Yang Zhao,Fu Lei Tang,Lei Xiong,Ce Su,Lin Mei,Lin Mei,Xiaojuan Zhu,Wen Cheng Xiong,Wen Cheng Xiong +10 more
TL;DR: P pHluorin-BACE1-mCherry fusion protein may serve as a useful tool for visualizing active/inactive BACE1 in culture and in vivo, and (pro)renin receptor (PRR), a subunit of the v-ATPase complex, regulates pHLUorin’s fluorescence and Bace1 activity in pHluorbase expressing cells.
Journal ArticleDOI
PRRT2 frameshift mutation reduces its mRNA stability resulting loss of function in paroxysmal kinesigenic dyskinesia
Yongcheng Pan,Qiong Liu,Jennifer Zhang,Yang Yang,Yun Tian,Junsheng Zeng,Peng Yin,Lin Mei,Wen Cheng Xiong,Xiao-Jiang Li,Shihua Li,Beisha Tang +11 more
TL;DR: These studies suggest that PRRT2 frameshift mutation leads to the loss of function by affecting its mRNA stability, a mechanism that is different from haploinsufficiency due to dysfunctional protein or gain of function caused by truncated protein.