L
Lin Mei
Researcher at Case Western Reserve University
Publications - 266
Citations - 18002
Lin Mei is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Neuromuscular junction & Agrin. The author has an hindex of 69, co-authored 245 publications receiving 15903 citations. Previous affiliations of Lin Mei include University of Arizona & Chinese Academy of Sciences.
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β-Catenin Interacts with MyoD and Regulates Its Transcription Activity
TL;DR: It is shown that β-catenin interacts directly with MyoD, a basic helix-loop-helix transcription factor essential for muscle differentiation and enhances its binding to E box elements and transcriptional activity.
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Wnt proteins regulate acetylcholine receptor clustering in muscle cells
TL;DR: These results identify Wnts as new players in AChR cluster formation, which act in a manner that requires both MuSK and LRP4, revealing a novel function of L RP4.
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YAP stabilizes SMAD1 and promotes BMP2-induced neocortical astrocytic differentiation.
Zhihui Huang,Jin-Xia Hu,Jin-Xiu Pan,Ying Wang,Guoqing Hu,Jiliang Zhou,Lin Mei,Wen Cheng Xiong +7 more
TL;DR: In the developing mouse neocortex, the YAP transcription factor is activated by BMP2 signaling, and in turn stabilises Smad1 to promote proliferation and differentiation of astrocytes.
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Erbin regulates NRG1 signaling and myelination.
Yanmei Tao,Penggao Dai,Yu Liu,Sylvie Marchetto,Sylvie Marchetto,Wen Cheng Xiong,Jean-Paul Borg,Jean-Paul Borg,Lin Mei +8 more
TL;DR: It is shown that Erbin, a protein that contains leucine-rich repeats and a PSD95-Dlg-Zol (PDZ) domain and that interacts specifically with ErbB2, is necessary for NRG1 signaling and myelination of peripheral nervous system (PNS).
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Lrp4 in astrocytes modulates glutamatergic transmission
Xiang Dong Sun,Lei Li,Fang Liu,Zhi Hui Huang,Jonathan C. Bean,Hui Feng Jiao,Arnab Barik,Seon Myung Kim,Haitao Wu,Chengyong Shen,Yun Tian,Thiri W. Lin,Ryan Bates,Anupama Sathyamurthy,Yong Jun Chen,Dong Min Yin,Lei Xiong,Hui Ping Lin,Jin Xia Hu,Bao Ming Li,Tian Ming Gao,Wen Cheng Xiong,Lin Mei +22 more
TL;DR: A critical role is revealed for Lrp4, in response to agrin, in modulating astrocytic ATP release and synaptic transmission in mice lacking low-density lipoprotein receptor–related protein 4, a protein that is critical for neuromuscular junction formation.