L
Lin Zhang
Researcher at Nanjing University
Publications - 7
Citations - 1358
Lin Zhang is an academic researcher from Nanjing University. The author has contributed to research in topics: Internal medicine & Viral replication. The author has an hindex of 4, co-authored 6 publications receiving 1139 citations.
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Journal ArticleDOI
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: Evidence of cross-kingdom regulation by microRNA
Lin Zhang,Dongxia Hou,Xi Chen,Donghai Li,Lingyun Zhu,Lingyun Zhu,Yujing Zhang,Jing Li,Zhen Bian,Xiangying Liang,Xing Cai,Yuan Yin,Cheng Wang,Tianfu Zhang,Dihan Zhu,Dianmu Zhang,Jie Xu,Qun Chen,Yi Ba,Jing Liu,Qiang Wang,Jian-Qun Chen,Jin Wang,Meng Wang,Qipeng Zhang,Junfeng Zhang,Ke Zen,Chen-Yu Zhang +27 more
TL;DR: It is shown that MIR168a could bind to the human/mouse low-density lipoprotein receptor adapter protein 1 (LDLRAP1) mRNA, inhibit LDLRAP1 expression in liver, and consequently decrease LDL removal from mouse plasma, demonstrating that exogenous plant miRNAs in food can regulate the expression of target genes in mammals.
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Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses
Zhen Zhou,Xihan Li,Jinxiong Liu,Lei Dong,Qun Chen,Jialing Liu,Huihui Kong,Qianyi Zhang,Xian Qi,Dongxia Hou,Lin Zhang,Guoquan Zhang,Yuchen Liu,Yujing Zhang,Jing Li,Jin Wang,Xi Chen,Hua Wang,Junfeng Zhang,Hualan Chen,Ke Zen,Chen-Yu Zhang +21 more
TL;DR: It is reported that MIR2911, a honeysuckle-encoded atypical microRNA, directly targets IAVs with a broad spectrum and may represent a novel type of natural product that effectively suppresses viral infection.
Journal ArticleDOI
Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients.
Lingyun Zhu,Qiang Wang,Lin Zhang,Zhixiang Fang,Fang Zhao,Zhiyuan Lv,Zuguang Gu,Junfeng Zhang,Jin Wang,Ke Zen,Yang Xiang,Dongjin Wang,Chen-Yu Zhang +12 more
TL;DR: It is shown that hypoxia can stimulate the expression of PGC-1α and mitochondrial biogenesis in the cardiac myocytes, and this process might provide a potential adaptive mechanism for cardiac myocyte to increase ATP output and minimize hypoxic damage to the heart.
Journal ArticleDOI
Erratum: Exogenous plant MIR168a specifically targets mammalian LDLRAP1: Evidence of cross-kingdom regulation by microRNA (Cell Research (2012) 22 DOI: 10.1038/cr.2011.174 (273-274))
Lin Zhang,Dongxia Hou,Xi Chen,Donghai Li,Lingyun Zhu,Lingyun Zhu,Yujing Zhang,Jing Li,Zhen Bian,Xiangying Liang,Xing Cai,Yuan Yin,Cheng Wang,Tianfu Zhang,Dihan Zhu,Dianmu Zhang,Jie Xu,Qun Chen,Yi Ba,Jing Liu,Qiang Wang,Jian-Qun Chen,Jin Wang,Meng Wang,Qipeng Zhang,Junfeng Zhang,Ke Zen,Chen-Yu Zhang +27 more
Journal ArticleDOI
Helicobacter pylori in the Oral Cavity: Current Evidence and Potential Survival Strategies
TL;DR: In this paper , the authors analyze the evidence indicating the existence of living oral Helicobacter pylori, as well as potential survival strategies, including the formation of a favorable microenvironment, the interaction between H. pyloris and oral microorganisms, and the transition to a non-growing state.