Qiang Wang

TL;DR: It is reported that secreted miRNAs can serve as signaling molecules mediating intercellular communication and demonstrate that cells can secrete miRNA and deliver them into recipient cells where the exogenous mi RNAs can regulate target gene expression and recipient cell function.

TL;DR: It is shown that MIR168a could bind to the human/mouse low-density lipoprotein receptor adapter protein 1 (LDLRAP1) mRNA, inhibit LDLRAP1 expression in liver, and consequently decrease LDL removal from mouse plasma, demonstrating that exogenous plant miRNAs in food can regulate the expression of target genes in mammals.

TL;DR: It is demonstrated that secretion of miR-150 via MVs can promote angiogenesis in vitro and in vivo, and a novel microRNA-based therapeutic approach for disease treatment is presented.

TL;DR: The posttranscriptional regulation of PGC-1α by miR-19b/221/222 was unveiled, which provides a novel mechanism in which a panel of microRNAs can modulate endothelial cell apoptosis via the regulation mitochondrial function.

TL;DR: It is shown that hypoxia can stimulate the expression of PGC-1α and mitochondrial biogenesis in the cardiac myocytes, and this process might provide a potential adaptive mechanism for cardiac myocyte to increase ATP output and minimize hypoxic damage to the heart.