Lin Zhi

TL;DR: This paper describes the design and preparation of a series of RXR selective retinoids as well as the biological data obtained from cotransfection and competitive binding assays which were used to evaluate their potency and selectivity.

TL;DR: An androgen receptor (AR) ligand that maintains expected anabolic activities with substantially diminished activity in the prostate and demonstrates the important role of the AR and androgens in mediating a number of beneficial effects in bone, muscle, and sexual function independent from the conversion of androgens into estrogenic ligands.

TL;DR: In this article, the authors describe compounds which are agonists of the progesterone receptor which have general structures, wherein the substituents are as defined; or a pharmaceutically acceptable salt thereof.

TL;DR: Investigations of structure-activity relationships surrounding this pharmacophore resulted in molecules with complete specificity for AR, antagonist activity on an AR mutant commonly observed in prostate cancer patients, and improved in vivo efficacy.

TL;DR: In this paper, non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed, as well as pharmaceutical compositions incorporating such compounds, methods for employing such compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy.