Mei Hua Hong

TL;DR: An androgen receptor (AR) ligand that maintains expected anabolic activities with substantially diminished activity in the prostate and demonstrates the important role of the AR and androgens in mediating a number of beneficial effects in bone, muscle, and sexual function independent from the conversion of androgens into estrogenic ligands.

TL;DR: The search for novel glucocorticoids that have reduced side effects in bone and other tissues is being driven by the identification of new mechanisms of action of the glucoc Corticoid receptor, which may facilitate the detection of new, safer therapies with efficacies equivalent to currently prescribed steroids.

TL;DR: Results indicate that AR expression in skeletal muscle fibers is not sufficient to rescue the male phenotype of the SNB neuromuscular system and suggest that AR in other cell types plays a critical role in sexual differentiation of this system.

TL;DR: This work has identified tissue-specific androgen-regulated genes in the skeletal muscle in rats after oral administration of androgens and focused on androgens-dependent up-regulation of the skeletal α-actin gene.

TL;DR: A series of novel non-peptidyl small molecules that selectively activate human GCSFR (hGCSFR) function are discovered, and may provide a significant innovation in the treatment of neutropenia.