L
Lin Zhu
Researcher at Capital Normal University
Publications - 365
Citations - 10291
Lin Zhu is an academic researcher from Capital Normal University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 45, co-authored 301 publications receiving 7341 citations. Previous affiliations of Lin Zhu include Icahn School of Medicine at Mount Sinai & Karolinska Institutet.
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Journal ArticleDOI
Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting
TL;DR: A novel "smart" multifunctional drug delivery system was successfully developed to respond to the up-regulated matrix metalloprotease 2 in the tumor microenvironment and improve cancer cell-specific delivery of loaded drugs.
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pH-sensitive poly(histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery.
TL;DR: The results of this study suggest that the mixed micelles (DSPE-PEG(2000)/DSPe-Peg(3400)-2C5/PHIS-P EG(2000)) could enhance the tumor cell-specific internalization and trigger the quick drug release, resulting in the improved anti-cancer efficacy.
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Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety.
TL;DR: The nanopreparation showed superior tumor targeting, cell internalization, and antitumor efficacy over its nonsensitive counterpart, free paclitaxel and conventional micelles, and has potential for effective intracellular delivery of drug into cancer cells.
Journal ArticleDOI
Sex differences in lipid and lipoprotein metabolism.
Brian T. Palmisano,Brian T. Palmisano,Lin Zhu,Robert H. Eckel,John M. Stafford,John M. Stafford,John M. Stafford +6 more
TL;DR: Evidence of how endogenous sex hormones and hormone treatment approaches impact fatty acid, triglyceride, and cholesterol metabolism to influence metabolic and cardiovascular risk is discussed.
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Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance
Lin Zhu,William Brown,Qing Cai,Andrée Krust,Pierre Chambon,Owen P. McGuinness,John M. Stafford,John M. Stafford +7 more
TL;DR: Estrogen treatment may reverse aspects of pathway-selective insulin resistance by promoting insulin action on glucose metabolism but limiting liver lipid deposition but limiting hepatic lipid deposition.