L
Linda M. Griffen
Researcher at University of Utah
Publications - 24
Citations - 1874
Linda M. Griffen is an academic researcher from University of Utah. The author has contributed to research in topics: Hemochromatosis & Transferrin saturation. The author has an hindex of 13, co-authored 24 publications receiving 1856 citations. Previous affiliations of Linda M. Griffen include LDS Hospital.
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Journal ArticleDOI
Prevalence of Hemochromatosis among 11,065 Presumably Healthy Blood Donors
Corwin Q. Edwards,Linda M. Griffen,David E. Goldgar,Charles Drummond,Mark H. Skolnick,James P. Kushner +5 more
TL;DR: The value of population screening is demonstrated in these studies by the detection of homozygotes before clinical manifestations of hemochromatosis occur, and the efficacy of transferrin saturation as a screening tool for hemochROMatosis is determined.
Journal ArticleDOI
Clinical and biochemical abnormalities in people heterozygous for hemochromatosis.
TL;DR: The phenotype of persons heterozygous for hemochromatosis differs from that of normal subjects, but complications due to iron overload alone in these heterozygotes are extremely rare.
Journal ArticleDOI
Disease-related conditions in relatives of patients with hemochromatosis
Zaneta J. Bulaj,Richard S. Ajioka,John D. Phillips,Bernie LaSalle,Lynn B. Jorde,Linda M. Griffen,Corwin Q. Edwards,James P. Kushner +7 more
TL;DR: A substantial number of homozygous relatives of patients with hemochromatosis--more commonly men than women--have conditions related to hemochROMatosis that have yet to be detected clinically.
Journal ArticleDOI
Hemochromatosis genes and other factors contributing to the pathogenesis of porphyria cutanea tarda
Zaneta J. Bulaj,John D. Phillips,Richard S. Ajioka,Michael R. Franklin,Linda M. Griffen,Donald J. Guinee,Corwin Q. Edwards,James P. Kushner +7 more
TL;DR: Homozygosity for the Cys282Tyr mutation and HCV are the greatest risk factors for expression of PCT, and in most patients, more than 1 risk factor was identified.
Journal ArticleDOI
Haplotype analysis of hemochromatosis: evaluation of different linkage-disequilibrium approaches and evolution of disease chromosomes.
Richard S. Ajioka,Lynn B. Jorde,Jeffrey R. Gruen,Ping Yu,Diana Dimitrova,Jalene Barrow,Evette S. Radisky,Corwin Q. Edwards,Linda M. Griffen,James P. Kushner +9 more
TL;DR: Analysis of the hereditary hemochromatosis locus suggests that the mutation associated with the most common haplotype occurred relatively recently and provides an evolutionary history for disease chromosomes.