L
Linda S. Wyatt
Researcher at National Institutes of Health
Publications - 111
Citations - 10155
Linda S. Wyatt is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Vaccinia & Virus. The author has an hindex of 51, co-authored 111 publications receiving 9664 citations. Previous affiliations of Linda S. Wyatt include Government of the United States of America & Office of Technology Transfer.
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Journal ArticleDOI
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
Rama Rao Amara,Francois Villinger,John D. Altman,Shari L. Lydy,Shawn P. O'Neil,Silvija I. Staprans,David C. Montefiori,Yan Xu,James G. Herndon,Linda S. Wyatt,Maria Angelito Candido,Natalia Kozyr,Patricia L. Earl,James M. Smith,Hak-Ling Ma,Hak-Ling Ma,Bennett D. Grimm,Michael L. Hulsey,Joseph I. Miller,Harold M. McClure,Janet M. McNicholl,Bernard Moss,Harriet L. Robinson +22 more
TL;DR: DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model, providing hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic.
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
Rama Rao Amara,Francois Villinger,John D. Altman,Shari L. Lydy,Shari L. Lydy,Shawn P. O'Neil,Shawn P. O'Neil,Silvija I. Staprans,David C. Montefiori,Yan Xu,James G. Herndon,Linda S. Wyatt,Maria Angelito Candido,Natalia L. Kozyr,Patricia L. Earl,James M. Smith,James M. Smith,Hak-Ling Ma,Hak-Ling Ma,Bennett D. Grimm,Michael L. Hulsey,Harold M. McClure,Janet M. McNicholl,Bernard Moss,Harriet L. Robinson,Harriet L. Robinson +25 more
TL;DR: DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster has controlled a highly pathogenic immunodeficiency virus challenge in a Rhesus macaque model, providing hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the AIDS epidemic.
Journal ArticleDOI
Isolation of a new herpesvirus from human CD4+ T cells
Niza Frenkel,Eric C. Schirmer,Linda S. Wyatt,George C. Katsafanas,Ehud Roffman,Robert M. Danovich,Carl H. June +6 more
TL;DR: It is concluded that the RK virus is distinct from previously characterized human herpesviruses, and proposed to designate it as the prototype of a new herpesv virus, the seventh human herpesvirus identified to date.
Journal ArticleDOI
Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox
Patricia L. Earl,Jeffrey L. Americo,Linda S. Wyatt,Leigh Anne Eller,J. Charles Whitbeck,Gary H. Cohen,Roselyn J. Eisenberg,Chris Hartmann,David L. Jackson,David A. Kulesh,Mark J. Martinez,David M. Miller,Eric M. Mucker,Joshua D. Shamblin,Susan H. Zwiers,John W. Huggins,Peter B. Jahrling,Bernard Moss +17 more
TL;DR: The highly attenuated modified vaccinia virus Ankara (MVA) with the licensed Dryvax vaccine in a monkey model is compared and unimmunized animals developed more than 500 pustular skin lesions and became gravely ill or died, whereas vaccinated animals were healthy and asymptomatic.
Journal ArticleDOI
A recombinant vector derived from the host range-restricted and highly attenuated MVA strain of vaccinia virus stimulates protective immunity in mice to influenza virus
TL;DR: Mice inoculated by various routes with recombinant MVA produced antibody and cytotoxic T-lymphocyte responses to influenza virus proteins and were protected against a lethal influenza virus challenge as effectively as mice immunized with a recombinant derived from the replication-competent WR strain of vaccinia virus.