L
Ling Li
Researcher at Fred Hutchinson Cancer Research Center
Publications - 10
Citations - 2802
Ling Li is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Transcription factor & Regulation of gene expression. The author has an hindex of 9, co-authored 10 publications receiving 2667 citations.
Papers
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Journal ArticleDOI
Rheb promotes cell growth as a component of the insulin/TOR signalling network
TL;DR: Genetic and biochemical tests indicate that Rheb functions in the insulin signalling pathway downstream of Tsc1–Tsc2 and upstream of TOR, suggesting a role for rheb in the nutritional control of cell growth.
Journal ArticleDOI
Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions
TL;DR: It is shown that inhibiting Inr/PI3K signaling phenocopies the cellular and organismal effects of starvation, whereas activating this pathway bypasses the nutritional requirement for cell growth, causing starvation sensitivity at the organismal level.
Journal ArticleDOI
Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network
Amir Orian,Bas van Steensel,Jeffrey J. Delrow,Harmen J. Bussemaker,Ling Li,Tomoyuki Sawado,Eleanor M. Williams,Lenora W. M. Loo,Shaun M. Cowley,Cynthia Yost,Sarah B. Pierce,Bruce A. Edgar,Susan M. Parkhurst,Robert N. Eisenman +13 more
TL;DR: The DamID method is employed to carry out global genomic mapping of the Drosophila Myc, Max, and Mad/Mnt proteins and suggests that a fundamental aspect of Max network function involves widespread binding and regulation of gene expression.
Dataset
Supplementary Data Only: Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network.
Amir Orian,Bas van Steensel,Jeffrey J. Delrow,Harmen J. Bussemaker,Ling Li,Tomoyuki Sawado,Eleanor M. Williams,Lenora W. M. Loo,Shaun M. Cowley,Cynthia Yost,Sarah B. Pierce,Bruce A. Edgar,Susan M. Parkhurst,Robert N. Eisenman +13 more
TL;DR: In this paper, DamID was employed to carry out global genomic mapping of the Drosophila Myc, Max, and Mad/Mnt proteins, and the results suggest that a fundamental aspect of Max network function involves widespread binding and regulation of gene expression.
Journal ArticleDOI
Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development.
TL;DR: It is suggested that during animal development, the control of rRNA synthesis and ribosome biogenesis is an essential Myc function.