L
Lingling Shan
Researcher at National Institutes of Health
Publications - 19
Citations - 1005
Lingling Shan is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Photothermal therapy & Arthritis. The author has an hindex of 13, co-authored 17 publications receiving 690 citations. Previous affiliations of Lingling Shan include Soochow University (Suzhou).
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Journal ArticleDOI
Organic Semiconducting Photoacoustic Nanodroplets for Laser-Activatable Ultrasound Imaging and Combinational Cancer Therapy.
Wei Tang,Zhen Yang,Sheng Wang,Zhantong Wang,Jibin Song,Guocan Yu,Wenpei Fan,Yunlu Dai,Jingjing Wang,Lingling Shan,Gang Niu,Quli Fan,Xiaoyuan Chen +12 more
TL;DR: The PS-PDI-PAnDs represents a type of PFC nanodroplets for synergistic PDT/PTT treatment upon a single laser irradiation, which is expected to hold great potential in the clinical translation in dual-modal PA/US imaging-guided combinational cancer therapy.
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Near‐Infrared Semiconducting Polymer Brush and pH/GSH‐Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor‐Specific Phototheranostics
Zhen Yang,Zhen Yang,Wenpei Fan,Wei Tang,Zheyu Shen,Yunlu Dai,Jibin Song,Zhantong Wang,Yuan Liu,Lisen Lin,Lingling Shan,Yijing Liu,Orit Jacobson,Pengfei Rong,Wei Wang,Xiaoyuan Chen +15 more
TL;DR: The smart pH/glutathione (GSH)-responsive SPB@POM allows for remarkablePhototheranostic enhancement under the unique TME, which has potential for precise tumor-specific phototheranostics with minimal side effects.
Journal ArticleDOI
Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy.
Wenpei Fan,Nan Lu,Zheyu Shen,Wei Tang,Bo Shen,Zhaowen Cui,Lingling Shan,Zhen Yang,Zhantong Wang,Orit Jacobson,Zijian Zhou,Yijing Liu,Ping Hu,Weijing Yang,Jibin Song,Yang Zhang,Liwen Zhang,Niveen M. Khashab,Maria A. Aronova,Guangming Lu,Xiaoyuan Chen +20 more
TL;DR: An ammonia-assisted hot water etching strategy for the generic synthesis of a library of small-sized hollow mesoporous organosilica nanoparticles with mono, double, triple, and even quadruple framework hybridization of diverse organic moieties designed for oxygen-independent X-ray-activated synergistic therapy.
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Salicin from Alangium chinense Ameliorates Rheumatoid Arthritis by Modulating the Nrf2-HO-1-ROS Pathways.
Ke-feng Zhai,Ke-feng Zhai,Hong Duan,Ghulam Jilany Khan,Ghulam Jilany Khan,Hui Xu,Fang-Kai Han,Cao Wengen,Guizhen Gao,Lingling Shan,Lingling Shan,Zhao-Jun Wei +11 more
TL;DR: It is indicated that salicin ameliorates rheumatoid arthritis, which may be associated with oxidative stress and Nrf2-HO-1-ROS pathways in RA-FLSs.
Journal ArticleDOI
Acidity/Reducibility Dual-Responsive Hollow Mesoporous Organosilica Nanoplatforms for Tumor-Specific Self-Assembly and Synergistic Therapy.
Wei Tang,Wenpei Fan,Zhantong Wang,Weizhong Zhang,Shiyi Zhou,Yijing Liu,Zhen Yang,Emily Shao,Guofeng Zhang,Orit Jacobson,Lingling Shan,Rui Tian,Siyuan Cheng,Lisen Lin,Yulun Dai,Zheyu Shen,Gang Niu,Jin Xie,Xiaoyuan Chen +18 more
TL;DR: An "ammonia-assisted hot water etching" method is applied for the successful construction of sub-50 nm thioether/phenylene dual-hybridized HMON with low hemolytic effect and holds significant potential in realizing TME-responsive self-assembly for enhanced tumor accumulation and precise tumor-specific synergistic therapy, which is very promising for clinical translation.