Linn M Eggesbø

TL;DR: Interestingly, genetic depletion of different Ikaros targets, including CTNND1 and the early hematopoietic cell surface marker CD34, resulted in reduced leukemic growth and the results suggest that IkarOS mediates tumor suppressing function by enforcing proper developmental stage–specific expression of multiple genes through chromatin compaction at its target genes.

TL;DR: It is found that CeD patients, both untreated and treated, had larger and more diverse γδ TCR repertoires, more frequent usage of TRDV1 andTRDV3 and different patterns of TCRγ/TCRδ-pairing compared with controls, and project challenges for identification of CeD-relevant γ Δ TCR ligands.

TL;DR: Single-cell analysis reveals an accumulation of short-lived disease-specific as well as non–disease-specific intestinal plasma cells in untreated and short-term–treated celiac disease.

TL;DR: In this article, the authors performed direct cell cloning of duodenal biopsies from five untreated and one refractory celiac disease patients, and three non-celiac disease control subjects in order to assess, in an unbiased fashion, the frequency of gluten-reactive T cells in the disease-affected tissue as well as the antigen fine specificity of the responding T cells.

TL;DR: In this paper, the authors examined the clonal relationship between cells of blood and gut during gluten exposure and found extensive sharing between blood and colon TCRs even prior to a gluten challenge.