Ida Lindeman

TL;DR: It is shown that Treg cells segregate into subpopulations along a continuum of tissue adaptation and present conserved expression programs between homeostasis and disease and mouse and human.

TL;DR: Single-cell RNA-seq was used to characterise CD4+ regulatory and memory T cells in mouse skin and colon, and reconstructed the mechanisms of cell migration and NLT adaption, identifying molecular signals mediating NLT Treg recruitment and tissue adaptation.

TL;DR: This work proposes a robust novel method for determining VDJ haplotypes by adapting a Bayesian framework, and attest its broad application with a large, multi-individual dataset.

TL;DR: BraCeR as discussed by the authors reconstructs full-length B-cell receptor sequences from single-cell RNA-sequencing (scRNA-seq) data, without having to perform additional targeted repertoire sequencing.

TL;DR: Interestingly, genetic depletion of different Ikaros targets, including CTNND1 and the early hematopoietic cell surface marker CD34, resulted in reduced leukemic growth and the results suggest that IkarOS mediates tumor suppressing function by enforcing proper developmental stage–specific expression of multiple genes through chromatin compaction at its target genes.