Lionel Chevolot

TL;DR: The composition, molecular weight, anticoagulant activity and nuclear magnetic resonance spectra of various low-molecular-weight fucans obtained by partial hydrolysis or radical depolymerization of a crude fucoidan extracted from the brown seaweed Ascophyllum nodosum are compared.

TL;DR: The predominant repeating structure of a fraction of the fucoidan from Ascophyllum nodosum prepared by acid hydrolysis and centrifugal partition chromatography (LMWF) has in vitro anticoagulant activity, indicating that the above structure may be partly responsible for biological activity in the nativefucoidan.

TL;DR: A new low-molecular-weight 'heparin-like' component was obtained from an exopolysaccharide produced by a mesophilic strain found in deep-sea hydrothermal vents, and co-electrophoresis studies suggested that a single population of polysaccharid chains binds to antithrombin and that only a subpopulation strongly interacts with heparin cofactor II.

TL;DR: The structure of the extracellular polysaccharide produced by the mesophilic species, Alteromonas infernus, found in deep-sea hydrothermal vents and grown under laboratory conditions, has been investigated using partial depolymerization, methylation analysis, mass spectrometry and NMR spectroscopy.

TL;DR: This study demonstrates that highly sulfated oligosaccharides from fucoidan can be analyzed by ESIMS which gives additional information about the structure of this highly complex polysaccharide.