Y
Yu-Jun Cai
Researcher at University of Rochester
Publications - 41
Citations - 2220
Yu-Jun Cai is an academic researcher from University of Rochester. The author has contributed to research in topics: DNA damage & Apoptosis. The author has an hindex of 26, co-authored 41 publications receiving 2031 citations. Previous affiliations of Yu-Jun Cai include Lanzhou University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Role of Ca2+/Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy
Clint L. Miller,Masayoshi Oikawa,Yu-Jun Cai,Andrew P. Wojtovich,David J. Nagel,Xiangbin Xu,Haodong Xu,Vince Florio,Sergei D. Rybalkin,Joseph A. Beavo,Yiu Fai Chen,Jian Dong Li,Burns C. Blaxall,Jun Ichi Abe,Chen Yan +14 more
TL;DR: The results elucidate a novel role for Ca2+/CaM–stimulated PDE1, particularly Pde1A, in regulating pathological cardiomyocyte hypertrophy via a cGMP/PKG–dependent mechanism, thereby demonstrating Ca2-and-cGMP signaling cross-talk during cardiachypertrophy.
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DNA damage induced by resveratrol and its synthetic analogues in the presence of Cu (II) ions: mechanism and structure-activity relationship.
TL;DR: Kinetic analysis by UV-visible spectra demonstrates that the formation of ArOH-Cu (II) complexes, the stabilization of oxidative intermediate derived from ArOH and Cu (II)/Cu (I) redox cycles, might be responsible for the DNA damage.
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Inhibition of free radical-induced peroxidation of rat liver microsomes by resveratrol and its analogues.
TL;DR: All of these trans-stilbene derivatives are effective antioxidants against both AAPH- and iron-induced peroxidation of rat liver microsomes with an activity sequence of 3,4-DHS >4,4'-DHS>resveratrol>4-HS>3,5-D HS.
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Cytotoxic and apoptotic activities of diarylheptanoids and gingerol-related compounds from the rhizome of Chinese ginger
TL;DR: SAR analysis demonstrates that the following structural determinants contribute critically to the enhancement of the activity of ginger: acetoxyl groups at 3- and/or 5-positions of the side chain; and the appropriate longer alkyl side-chain length.
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Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes
TL;DR: Kinetic analysis of the antioxidation process demonstrates that these green tea polyphenols (GOHs), especially EC and ECG which bear ortho-dihydroxyl functionality, are good antioxidants for microsomal peroxidation.