Lisa Pan

TL;DR: A biological, neurocognitive basis for altered concept representations in participants with suicidal ideation is established, which enables highly accurate group membership classification, and a highly accurate biological classification method is developed by applying machine learning to neural representations of death- and life-related concepts.

TL;DR: Elevated activity in attention control circuitry, and reduced anterior cingulate gyral–insula functional connectivity, to 50% intensity angry faces in ATT than other groups suggest that ATT may show inefficient recruitment of attentional control neural circuitry when regulating attention to mild intensity Angry faces, which may represent a potential biological marker for suicide risk.

TL;DR: Findings indicate that suicide attempts during adolescence are not associated with abnormal activity in response inhibition neural circuitry and suggest different neural mechanisms for suicide attempt versus major depressive disorder in general in adolescence that should be a focus of further study.

TL;DR: The first group compared with controls showed reduction in grey-matter volume in the right superior temporal gyrus (BA38), a region important for social emotion processing and regulation neural circuitry in adolescents with a history of suicide attempt.

TL;DR: Functional abnormalities in neural circuitry implicated in learning in the context of risk may underlie risk for MDD, but not risk for suicide attempt, in adolescence.