L
Lisa Robson
Researcher at Alexandra Hospital
Publications - 64
Citations - 2013
Lisa Robson is an academic researcher from Alexandra Hospital. The author has contributed to research in topics: Cytogenetics & Fluorescence in situ hybridization. The author has an hindex of 22, co-authored 64 publications receiving 1973 citations. Previous affiliations of Lisa Robson include Johns Hopkins University School of Medicine & Royal Prince Alfred Hospital.
Papers
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Journal ArticleDOI
Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library.
Richard H. J. Begent,M. J. Verhaar,KA Chester,Joanne L. Casey,AJ Green,M.P. Napier,L.D Hope‐Stone,N. Cushen,P. A. Keep,CJ Johnson,Robert E. Hawkins,Andrew J.W. Hilson,Lisa Robson +12 more
TL;DR: The benefits of this system for cancer targeting based on single–chain Fv (scFv) antibodies selected from combinatorial libraries, produced in bacteria and purified by using an engineered tag are illustrated.
Journal ArticleDOI
Morbidity and mortality attributable to alcohol, tobacco, and illicit drug use in Canada
TL;DR: Substance abuse exacts a considerable toll on Canadian society in terms of morbidity and mortality, accounting for 21% of deaths, 23% of years of potential life lost, and 8% of hospitalizations.
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Phage libraries for generation of clinically useful antibodies
KA Chester,Richard H. J. Begent,Lisa Robson,P. A. Keep,RB Pedley,J.A. Boden LIBiol,GM Boxer,AJ Green,Greg Winter,O. Cochet,Robert E. Hawkins +10 more
TL;DR: This work used the insertion of antibody genes into filamentous bacteriophage to produce an antibody to carcinoembryonic antigen with higher affinity and better tumour specificity than antibodies currently in use.
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Purification of bacterially expressed single chain Fv antibodies for clinical applications using metal chelate chromatography
TL;DR: A new procedure is described for the purification of an anti-carcinoembryonic antigen (CEA) single chain Fv, referred to as MFE-23, from bacterial supernatant using a simple insertion of a hexa-histidine tail fused at the C-terminus, which proved to be superior to standard CEA antigen affinity chromatography.
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A phase I and pharmacokinetic study of paclitaxel poliglumex (XYOTAX), investigating both 3-weekly and 2-weekly schedules.
Alan V. Boddy,Elizabeth Ruth Plummer,R Todd,Julieann Sludden,MJ Griffin,Lisa Robson,Jim Cassidy,Donald Bissett,A Bernareggi,Mark Verrill,Alan Hilary Calvert +10 more
TL;DR: PPX is a water-soluble paclitaxel-polymer conjugate with a prolonged half-life and limited volume of distribution and dose-limiting toxicities were neutropenia and neuropathy.