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Liu-Zhu Gong

Researcher at University of Science and Technology of China

Publications -  61
Citations -  3508

Liu-Zhu Gong is an academic researcher from University of Science and Technology of China. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 29, co-authored 61 publications receiving 3340 citations. Previous affiliations of Liu-Zhu Gong include Chinese Academy of Sciences & Nankai University.

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Design of organocatalysts for asymmetric direct syn-aldol reactions

TL;DR: Two new organocatalysts 3a and 3b, derived from L-leucine and (S)-beta-amino alcohols, were designed and afforded the direct syn-aldol reactions of a wide scope of aldehydes with various ketones with an excellent diastereomeric ratio of up to >20/1 and enantioselectivities ofup to 99% ee.
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Organocatalyzed highly enantioselective direct aldol reactions of aldehydes with hydroxyacetone and fluoroacetone in aqueous media: the use of water to control regioselectivity.

TL;DR: An organocatalyst prepared from (2R,3R)-diethyl 2-amino-3-hydroxysuccinate and L-proline exhibited high regio- and enantioselectivities for the direct aldol reactions of hydroxyacetone and fluoroacetone with aldehydes in aqueous media and it was found that water could be used to control the regioselectivity.
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The rational design of novel chiral oxovanadium(IV) complexes for highly enantioselective oxidative coupling of 2-naphthols.

TL;DR: Several chiral oxovanadium(IV) complexes have been designed and prepared for the asymmetric catalytic oxidative coupling of 2-naphthols with high enantioselectivities of 83-98% ee.
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Design of highly enantioselective organocatalysts based on molecular recognition.

TL;DR: A linear effect was observed for the reaction, demonstrating a single molecule of the catalyst involved in theCatalysis of ketones with aryl and alkyl alpha-keto acids.
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Asymmetric direct aldol reaction catalyzed by an L-prolinamide derivative: considerable improvement of the catalytic efficiency in the ionic liquid

TL;DR: The asymmetric direct aldol reactions of a wide scope of aldehydes with unmodified ketones in the presence of 20 mol%( S,S,S)-pyrrolidine-2-carboxylic acid and 2'-hydroxyl-1',2'-diphenyl-ethyl)-amine were performed.