L
Lloyd J. Edwards
Researcher at University of Alabama at Birmingham
Publications - 134
Citations - 8182
Lloyd J. Edwards is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Mixed model & Generalized linear mixed model. The author has an hindex of 44, co-authored 126 publications receiving 7353 citations. Previous affiliations of Lloyd J. Edwards include Veterans Health Administration & University of North Carolina at Chapel Hill.
Papers
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Journal ArticleDOI
A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis
Michael R. Knowles,Kathy Hohneker,Zhaoqing Zhou,John C. Olsen,Terry L. Noah,Ping Chuan hu,Margaret W. Leigh,John F. Engelhardt,Lloyd J. Edwards,Kim R. Jones,Mariann Grossman,James M. Wilson,Larry G. Johnson,Richard C. Boucher +13 more
TL;DR: In patients with cystic fibrosis, adenoviral-vector-mediated transfer of the CFTR gene did not correct functional defects in nasal epithelium, and local inflammatory responses limited the dose of adenvirus that could be administered to overcome the inefficiency of gene transfer.
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Nontuberculous mycobacteria. I: multicenter prevalence study in cystic fibrosis.
Kenneth N. Olivier,David J. Weber,Richard J. Wallace,Ali R. Faiz,Ji-Hyun Lee,Yansheng Zhang,Barbara A. Brown-Elliot,Allison Handler,Rebecca W. Wilson,Michael S. Schechter,Lloyd J. Edwards,Subha Chakraborti,Michael R. Knowles +12 more
TL;DR: NTM are common in patients with CF, but neither person-to-person nor nosocomial acquisition explained the high prevalence, and older age was the most significant predictor for isolation of NTM.
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An R2 statistic for fixed effects in the linear mixed model.
TL;DR: This work defines and describes how to compute a model R(2) statistic for the linear mixed model by using only a single model and indicates that ethnicity has an almost negligible association with the repeated BP outcomes for the study.
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Longitudinal analysis of pulmonary function decline in patients with cystic fibrosis
TL;DR: All but the most severely affected patients, who died before age 15, appear to have had normal pulmonary function when first tested in early childhood, and Pancreatic sufficiency, male gender, and some non-delta F508 mutations are associated with a slower rate of pulmonary function decline.
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A Pilot Study of Aerosolized Amiloride for the Treatment of Lung Disease in Cystic Fibrosis
Michael R. Knowles,Nina L. Church,William E. Waltner,James R. Yankaskas,Peter H. Gilligan,Malcolm King,Lloyd J. Edwards,Ronald W. Helms,Richard C. Boucher +8 more
TL;DR: It is concluded from this preliminary study that aerosolized amiloride can be safely administered to adults with cystic fibrosis and the slowing of the loss of FVC and the improvement in sputum viscosity and elasticity suggest a beneficial clinical effect.