Z
Zhaoqing Zhou
Researcher at University of North Carolina at Chapel Hill
Publications - 14
Citations - 2091
Zhaoqing Zhou is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cystic fibrosis & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 9, co-authored 10 publications receiving 2038 citations.
Papers
More filters
Journal ArticleDOI
A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis
Michael R. Knowles,Kathy Hohneker,Zhaoqing Zhou,John C. Olsen,Terry L. Noah,Ping Chuan hu,Margaret W. Leigh,John F. Engelhardt,Lloyd J. Edwards,Kim R. Jones,Mariann Grossman,James M. Wilson,Larry G. Johnson,Richard C. Boucher +13 more
TL;DR: In patients with cystic fibrosis, adenoviral-vector-mediated transfer of the CFTR gene did not correct functional defects in nasal epithelium, and local inflammatory responses limited the dose of adenvirus that could be administered to overcome the inefficiency of gene transfer.
Journal ArticleDOI
A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chloride concentrations
W. Edward Highsmith,Lauranell H. Burch,Zhaoqing Zhou,John C. Olsen,Thomas E. Boat,Alexander Spock,Jack D. Gorvoy,Lynne M. Quittell,Kenneth J. Friedman,Lawrence M. Silverman,Richard C. Boucher,Michael R. Knowles +11 more
TL;DR: A point mutation in intron 19 of CFTR and abnormal epithelial function in patients who have cystic fibrosis-like lung disease but normal sweat chloride values is identified, indicating that this syndrome is a form of cystic Fibrosis.
Journal ArticleDOI
Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism
Eitan Kerem,T. Bistritzer,Aaron Hanukoglu,T. Hofmann,Zhaoqing Zhou,William D. Bennett,E. Maclaughlin,Pierre M. Barker,M. Nash,Lynne M. Quittell,Richard C. Boucher,Michael R. Knowles +11 more
TL;DR: It is demonstrated that sodium transport has a role in regulating the volume of liquid on airway surfaces in patients with systemic pseudohypoaldosteronism, a salt-losing disorder caused by loss-of-function mutations in the genes for the epithelial sodium channel.
Journal ArticleDOI
Cystic fibrosis gene mutations and pancreatitis risk: Relation to epithelial ion transport and trypsin inhibitor gene mutations
Peadar G. Noone,Zhaoqing Zhou,Lawrence M. Silverman,Paul S. Jowell,Michael R. Knowles,Jonathan A. Cohn +5 more
TL;DR: CFTR-related pancreatitis risk correlates with having 2 CFTR mutations and reduced extrapancreatic CFTR function, which may be useful in nonalcoholic pancreatitis.
Journal ArticleDOI
Safety and biological efficacy of a lipid-CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis.
Peadar G. Noone,Katherine W. Hohneker,Zhaoqing Zhou,Larry G. Johnson,Carla Foy,Clay L. Gipson,Kim R. Jones,Terry L. Noah,Margaret W. Leigh,Caryl Schwartzbach,John Efthimiou,Rodney Pearlman,Richard C. Boucher,Michael R. Knowles +13 more
TL;DR: It is concluded that the lipid-DNA complex is safe, but did not produce consistent evidence of gene transfer to the nasal epithelium by physiologic or molecular measures.