L
Lokesh Gakhar
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 67
Citations - 2488
Lokesh Gakhar is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Biology & Ubiquitin. The author has an hindex of 25, co-authored 62 publications receiving 2133 citations. Previous affiliations of Lokesh Gakhar include Mayo Clinic & Massachusetts Institute of Technology.
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Journal ArticleDOI
Rieske business: structure-function of Rieske non-heme oxygenases.
TL;DR: Rieske non-heme iron oxygenases catalyze stereo- and regiospecific reactions and the orientation of binding of the substrate to the enzyme is hypothesized to control the substrate selectivity and regio-specificity of product formation.
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Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia
Hongpeng Jia,Dwight C. Look,Ping Tan,Lei Shi,Melissa Hickey,Lokesh Gakhar,Mark C. Chappell,Christine L. Wohlford-Lenane,Paul B. McCray +8 more
TL;DR: It is reported that ACE2 is shed from human airway epithelia, a site of SARS-CoV infection and soluble ACE2 might play a role in modifying inflammatory processes at the airway mucosal surface.
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Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia
Nancy B. Ray,Lakshmi Durairaj,Bill B. Chen,Bryan J. McVerry,Alan J. Ryan,Michael P. Donahoe,Alisa K. Waltenbaugh,Christopher P. O'Donnell,Florita C. Henderson,Christopher A Etscheidt,Diann M. McCoy,Marianna Agassandian,Emily C Hayes-Rowan,Tiffany A. Coon,Phillip L Butler,Lokesh Gakhar,Satya N. Mathur,Jessica C. Sieren,Yulia Y. Tyurina,Valerian E. Kagan,Geoffrey McLennan,Rama K. Mallampalli +21 more
TL;DR: It is shown that humans and mice with bacterial pneumonia have markedly elevated amounts of cardiolipin, a rare, mitochondrial-specific phospholipid, in lung fluid and it is found that it potently disrupts surfactant function.
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PLUNC Is a Novel Airway Surfactant Protein with Anti-Biofilm Activity
Lokesh Gakhar,Jennifer A. Bartlett,Jon Penterman,Dario Mizrachi,Pradeep K. Singh,Rama K. Mallampalli,S. Ramaswamy,Paul B. McCray +7 more
TL;DR: The data suggest that the PLUNC protein contributes to the surfactant properties of airway secretions, and that this activity may interfere with biofilm formation by an airway pathogen.
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Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange
TL;DR: The X-ray crystal structure of monoubiquitinated PCNA is determined and it is proposed that PCNA ubiquitination facilitates nonclassical polymerase recruitment to the back of PCNA by forming a new binding surface for non classical polymerases, consistent with a 'tool belt' model of the polymerase exchange.