L
Long Xie
Researcher at University of Pennsylvania
Publications - 73
Citations - 1722
Long Xie is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Temporal lobe. The author has an hindex of 15, co-authored 54 publications receiving 1037 citations. Previous affiliations of Long Xie include Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Automated Volumetry and Regional Thickness Analysis of Hippocampal Subfields and Medial Temporal Cortical Structures in Mild Cognitive Impairment
Paul A. Yushkevich,John Pluta,Hongzhi Wang,Long Xie,Songlin Ding,Eske Christiane Gertje,Eske Christiane Gertje,Lauren Mancuso,Daria Kliot,Sandhitsu R. Das,David A. Wolk +10 more
TL;DR: Thickness analysis results are consistent with volumetry, but provide additional regional specificity and suggest nonuniformity in the effects of aMCI on hippocampal subfields and MTL cortical subregions.
Journal ArticleDOI
Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study.
Aaron M. Koenig,Dawn Mechanic-Hamilton,Sharon X. Xie,Martha F. Combs,Anne R. Cappola,Long Xie,John A. Detre,David A. Wolk,Steven E. Arnold +8 more
TL;DR: Metformin was associated with improved executive functioning, and trends suggested improvement in learning/memory and attention, and post hoc completer analyses suggested an increase in orbitofrontal cerebral blood flow with metformin exposure.
Journal ArticleDOI
Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology.
Daniel H. Adler,Laura E.M. Wisse,Ranjit Ittyerah,John Pluta,Songlin Ding,Long Xie,Jiancong Wang,Salmon Kadivar,John L. Robinson,Theresa Schuck,John Q. Trojanowski,Murray Grossman,John A. Detre,Mark A. Elliott,Jon B. Toledo,Weixia Liu,Stephen Pickup,Michael I. Miller,Sandhitsu R. Das,David A. Wolk,Paul A. Yushkevich +20 more
TL;DR: High-resolution ex vivo MRI scans of 31 human hippocampal specimens are combined using a groupwise diffeomorphic registration approach into a 3D probabilistic atlas that captures average anatomy and anatomic variability of hippocampal subfields, finding three-dimensional patterns of variability and disease and aging effects discovered via the ex vivo hippocampus atlas.
Journal ArticleDOI
A protocol for manual segmentation of medial temporal lobe subregions in 7 Tesla MRI.
David Berron,David Berron,Paula Vieweg,A. Hochkeppler,John Pluta,Songlin Ding,Anne Maass,Anica Luther,Long Xie,Sandhitsu R. Das,David A. Wolk,Thomas Wolbers,Paul A. Yushkevich,Emrah Düzel,Laura E.M. Wisse +14 more
TL;DR: This study presents a fine-grained and comprehensive segmentation protocol for MTL structures at 7 T MRI that closely follows recent knowledge from anatomical studies and provides detailed instructions alongside slice-by-slice segmentations to ease learning for the untrained but also more experienced raters.
Journal ArticleDOI
Artificial Intelligence System Approaching Neuroradiologist-level Differential Diagnosis Accuracy at Brain MRI.
Andreas M. Rauschecker,Jeffrey D. Rudie,Long Xie,Jiancong Wang,Michael Tran Duong,Emmanuel J. Botzolakis,Asha M Kovalovich,John M. Egan,Tessa C Cook,R. Nick Bryan,Ilya M. Nasrallah,Suyash Mohan,James C. Gee +12 more
TL;DR: An artificial intelligence system for brain MRI approached overall top one, top two, and top three differential diagnoses accuracy of neuroradiologists and exceeded that of less-specialized radiologists.