Longyan Jiang

TL;DR: Regardless of the presence of cirrhosis, patients with CHB, TB and INR ≥12 mg/dL and InR ≥1.5 should be diagnosed with ACLF, thus increasing their opportunity to receive timely intensive management.

TL;DR: Immediate IPT of hBMSCs is a safe and effective treatment for FHF and may quickly participate in liver regeneration via proliferation and transdifferentiation into hepatocytes during the initial stage of FHF.

TL;DR: The successful transdifferentiation rates of BMSCs to mature hepatocytes prove the superiority of the C-PLGA scaffold in providing a suitable environment for such a differentiation.

TL;DR: An integrated model of the multifaceted interactions between stem cells and recipients is delineated, which may open a new avenue to the discovery of single molecule-based therapeutics that simulate stem cell actions.

TL;DR: The genome-wide methylation profile of purified single hepatocytes of HBHC was aided in understanding the process of tumorigenesis, and a series of novel methylated genes found in this study have the potential to be biomarkers for the diagnosis and prognosis of HCC.