R
Ran Tao
Researcher at Vanderbilt University Medical Center
Publications - 210
Citations - 5575
Ran Tao is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 32, co-authored 115 publications receiving 4034 citations. Previous affiliations of Ran Tao include Vanderbilt University & National Institutes of Health.
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Journal ArticleDOI
Temporal dynamics and genetic control of transcription in the human prefrontal cortex
Carlo Colantuoni,Barbara K. Lipska,Tianzhang Ye,Thomas M. Hyde,Thomas M. Hyde,Ran Tao,Jeffrey T. Leek,Elizabeth Colantuoni,Abdel G. Elkahloun,Mary M. Herman,Daniel R. Weinberger,Daniel R. Weinberger,Joel E. Kleinman +12 more
TL;DR: The temporal dynamics and genetic control of transcription in human prefrontal cortex in an extensive series of post-mortem brains from fetal development through ageing is explored, finding a wave of gene expression changes occurring during fetal development which are reversed in early postnatal life.
Journal ArticleDOI
Genetic analyses of diverse populations improves discovery for complex traits
Genevieve L. Wojcik,Mariaelisa Graff,Katherine K. Nishimura,Ran Tao,Jeffrey Haessler,Christopher R. Gignoux,Christopher R. Gignoux,Heather M. Highland,Yesha Patel,Elena P. Sorokin,Christy L. Avery,Gillian M. Belbin,Stephanie A. Bien,Iona Cheng,Sinead Cullina,Chani J. Hodonsky,Yao Hu,Laura M. Huckins,Janina M. Jeff,Anne E. Justice,Jonathan M. Kocarnik,Unhee Lim,Bridget M Lin,Yingchang Lu,Sarah C. Nelson,Sungshim L. Park,Hannah Poisner,Michael Preuss,Melissa A. Richard,Claudia Schurmann,Claudia Schurmann,Veronica Wendy Setiawan,Alexandra Sockell,Karan Vahi,Marie Verbanck,Abhishek Vishnu,Ryan W. Walker,Kristin L. Young,Niha Zubair,Victor Acuña-Alonso,José Luis Ambite,Kathleen C. Barnes,Eric Boerwinkle,Erwin P. Bottinger,Erwin P. Bottinger,Carlos Bustamante,Christian Caberto,Samuel Canizales-Quinteros,Matthew P. Conomos,Ewa Deelman,Ron Do,Kimberly F. Doheny,Lindsay Fernández-Rhodes,Lindsay Fernández-Rhodes,Myriam Fornage,Benyam Hailu,Gerardo Heiss,Brenna M. Henn,Lucia A. Hindorff,Rebecca D. Jackson,Cecelia A. Laurie,Cathy C. Laurie,Yuqing Li,Yuqing Li,Danyu Lin,Andrés Moreno-Estrada,Girish N. Nadkarni,Paul Norman,Loreall Pooler,Alexander P. Reiner,Jane Romm,Chiara Sabatti,Karla Sandoval,Xin Sheng,Eli A. Stahl,Daniel O. Stram,Timothy A. Thornton,Christina L. Wassel,Lynne R. Wilkens,Cheryl A. Winkler,Sachi Yoneyama,Steven Buyske,Christopher A. Haiman,Charles Kooperberg,Loic Le Marchand,Ruth J. F. Loos,Tara C. Matise,Kari E. North,Ulrike Peters,Eimear E. Kenny,Christopher S. Carlson +90 more
TL;DR: The value of diverse, multi-ethnic participants in large-scale genomic studies is demonstrated and evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts and insights into clinical implications are shown.
Journal ArticleDOI
DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex
Shusuke Numata,Tianzhang Ye,Tianzhang Ye,Thomas M. Hyde,Thomas M. Hyde,Xavier Guitart-Navarro,Ran Tao,Michael Wininger,Carlo Colantuoni,Carlo Colantuoni,Daniel R. Weinberger,Daniel R. Weinberger,Joel E. Kleinman,Barbara K. Lipska +13 more
TL;DR: The results indicate that promoter DNA methylation in the human PFC is a highly dynamic process modified by genetic variance and regulating gene transcription, which correlates with expression of a subset of genes, including genes involved in brain development and in de novoDNA methylation.
Journal ArticleDOI
An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk.
Lang Wu,Yaohua Yang,Xingyi Guo,Xiao-Ou Shu,Qiuyin Cai,Xiang Shu,Bingshan Li,Bingshan Li,Ran Tao,Chong Wu,Jason B. Nikas,Yanfa Sun,Yanfa Sun,Jingjing Zhu,Monique J. Roobol,Graham G. Giles,Graham G. Giles,Hermann Brenner,Esther M. John,Judith A. Clements,Judith A. Clements,Eli Marie Grindedal,Jong Y. Park,Janet L. Stanford,Janet L. Stanford,Zsofia Kote-Jarai,Christopher A. Haiman,Rosalind A. Eeles,Wei Zheng,Jirong Long +29 more
TL;DR: DNA methylation biomarkers associated with PrCa are identified and the findings suggest that specific CpG sites may influence PrCa via regulating expression of candidate PrCa target genes.
Journal ArticleDOI
Dynamic regulation of RNA editing in human brain development and disease
Taeyoung Hwang,Chul-Kee Park,Anthony K.L. Leung,Yuan Gao,Thomas M. Hyde,Joel E. Kleinman,Anandita Rajpurohit,Ran Tao,Joo Heon Shin,Daniel R. Weinberger +9 more
TL;DR: Three unique patterns of A-to-I RNA editing rates during cortical development are identified: stable high, stable low and increasing, revealing global and dynamic aspects of RNA editing in brain, providing new insight into epitranscriptional regulation of sequence diversity.