Lorena Rodriguez

TL;DR: Results show that different modifications to the ALA molecule lead to different uptake mechanisms, and knowledge of the mechanisms of ALA derivatives entry into the cells is essential to understand and improve ALA‐mediated PDT and to the design of new ALA derivative that may be taken up at a higher rate than ALA.

TL;DR: In vivo and in vitro, the conjugation of ALA to a second-generation dxcendrimer for enhancing porphyrin synthesis in vitro and in vivo in a murine tumour model using systemic i.p. administration of 5-aminolaevulinic acid (ALA) showed good correlation with higher cellular ALA dendrimer accumulation.

TL;DR: The main finding of this work was that some derivatives have the potential to improve 5-aminolevulinic acid-based photodynamic therapy by increased efficiency of transport into cells expressing PEPT2 such as kidney, mammary gland, brain or lung whereas in tissues expressing exclusively P EPT1 the parent 5-AML acid remains the compound of choice.

TL;DR: The three formulations containing ALA or derivatives were stable up to 1 week upon storage at 4 degrees C, but upon dilution with medium, ALA leaked from the liposomes, while on the contrary, He-ALA was highly retained, being therefore a good choice for its use in PDT.

TL;DR: It was demonstrated that PDT strongly affects cell-cell and cell-substrate adhesion through the reorganization of some cytoskeletal and adhesion proteins.