Lorena Zentilin

TL;DR: It is shown that the exogenous administration of selected microRNAs (miRNAs) markedly stimulates cardiomyocyte proliferation and promotes cardiac repair and the miRNAs identified hold great promise for the treatment of cardiac pathologies consequent to cardiomeocyte loss.

TL;DR: It is shown that expression of human microRNA-199a in infarcted pig hearts can stimulate cardiac repair and achieving cardiac repair through the stimulation of endogenous cardiomyocyte proliferation is attainable in large mammals, however dosage of this therapy needs to be tightly controlled.

TL;DR: An easy and reliable method for the construction and quantification of competitive templates obtained as recombinant PCR products was developed and the technique was used for the absolute quantifying of human genomic DNA with primers from a single copy, subtelomeric region of chromosome 19.

TL;DR: It is shown that the delivery of the 165-aa isoform of VEGF-A cDNA using an adeno-associated virus (AAV) vector exerts a powerful effect on skeletal muscle regeneration in vivo and is consistent with the observation that V EGF promotes the growth of myogenic fibers and protects the myogenic cells from apoptosis in vitro.

TL;DR: This work reports the systematic analysis of 41 consecutive post-mortem samples from individuals who died of COVID-19, a unique disease characterized by extensive lung thrombosis, long-term persistence of viral RNA in pneumocytes and endothelial cells, along with the presence of infected cell syncytia.