L
Luca Braga
Researcher at International Centre for Genetic Engineering and Biotechnology
Publications - 36
Citations - 1827
Luca Braga is an academic researcher from International Centre for Genetic Engineering and Biotechnology. The author has contributed to research in topics: Medicine & Regeneration (biology). The author has an hindex of 13, co-authored 26 publications receiving 700 citations. Previous affiliations of Luca Braga include AREA Science Park & King's College London.
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Journal ArticleDOI
The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets.
Thomas P. Peacock,Daniel H. Goldhill,Jie Zhou,Laury Baillon,Rebecca Frise,Olivia C. Swann,Ruthiran Kugathasan,Rebecca Penn,Jonathan Brown,Raul Y. Sanchez-David,Luca Braga,Maia Kavanagh Williamson,Jack A. Hassard,Ecco Staller,Brian Hanley,Michael Osborn,Mauro Giacca,Andrew D. Davidson,David A. Matthews,Wendy S. Barclay +19 more
TL;DR: In this article, the authors show that the polybasic insertion of SARS-CoV-2 has a poly-basic insertion (PRRAR) at the S1/S2 cleavage site that can be cleaved by furin.
Journal ArticleDOI
MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs
Khatia Gabisonia,Giulia Prosdocimo,Giovanni Donato Aquaro,Lucia Carlucci,Lorena Zentilin,Ilaria Secco,Ilaria Secco,Hashim Ali,Hashim Ali,Luca Braga,Luca Braga,Nikoloz Gorgodze,Fabio Bernini,Silvia Burchielli,Chiara Collesi,Chiara Collesi,Lorenzo Zandonà,Gianfranco Sinagra,Marcello Piacenti,Serena Zacchigna,Serena Zacchigna,Rossana Bussani,Fabio A. Recchia,Fabio A. Recchia,Mauro Giacca,Mauro Giacca,Mauro Giacca +26 more
TL;DR: It is shown that expression of human microRNA-199a in infarcted pig hearts can stimulate cardiac repair and achieving cardiac repair through the stimulation of endogenous cardiomyocyte proliferation is attainable in large mammals, however dosage of this therapy needs to be tightly controlled.
Journal ArticleDOI
Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology
Rossana Bussani,Edoardo Schneider,Lorena Zentilin,Chiara Collesi,Hashim Ali,Luca Braga,Maria Concetta Volpe,Andrea Colliva,Fabrizio Zanconati,Giorgio Berlot,Furio Silvestri,Serena Zacchigna,Serena Zacchigna,Mauro Giacca,Mauro Giacca,Mauro Giacca +15 more
TL;DR: This work reports the systematic analysis of 41 consecutive post-mortem samples from individuals who died of COVID-19, a unique disease characterized by extensive lung thrombosis, long-term persistence of viral RNA in pneumocytes and endothelial cells, along with the presence of infected cell syncytia.
Journal ArticleDOI
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia.
Luca Braga,Hashim Ali,Ilaria Secco,Elena Chiavacci,Guilherme Neves,Daniel H. Goldhill,Rebecca Penn,Jose M. Jimenez-Guardeño,Ana Maria Ortega-Prieto,Rossana Bussani,Antonio Cannatà,Giorgia Rizzari,Chiara Collesi,Chiara Collesi,Edoardo Schneider,Edoardo Schneider,Daniele Arosio,Ajay M. Shah,Wendy S. Barclay,Michael H. Malim,Juan Burrone,Mauro Giacca,Mauro Giacca,Mauro Giacca +23 more
TL;DR: In this paper, the authors performed high-content microscopy-based screening with more than 3,000 approved drugs to search for inhibitors of spike-driven syncytia.
Journal ArticleDOI
The History and Mystery of Alveolar Epithelial Type II Cells: Focus on Their Physiologic and Pathologic Role in Lung.
Barbara Ruaro,Francesco Salton,Luca Braga,Barbara Wade,Paola Confalonieri,Maria Concetta Volpe,Elisa Baratella,Serena Maiocchi,Marco Confalonieri +8 more
TL;DR: A review of the role of alveolar type II (ATII) cells in pulmonary diseases can be found in this paper, where the origin, phenotypic regulation and crosstalk of these cells still remain a mystery.