M
Miguel Mano
Researcher at University of Coimbra
Publications - 60
Citations - 4251
Miguel Mano is an academic researcher from University of Coimbra. The author has contributed to research in topics: Cell-penetrating peptide & Peptide. The author has an hindex of 27, co-authored 56 publications receiving 3560 citations. Previous affiliations of Miguel Mano include International Centre for Genetic Engineering and Biotechnology.
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Journal ArticleDOI
Functional screening identifies miRNAs inducing cardiac regeneration
Ana Eulalio,Miguel Mano,Matteo Dal Ferro,Matteo Dal Ferro,Lorena Zentilin,Gianfranco Sinagra,Serena Zacchigna,Mauro Giacca +7 more
TL;DR: It is shown that the exogenous administration of selected microRNAs (miRNAs) markedly stimulates cardiomyocyte proliferation and promotes cardiac repair and the miRNAs identified hold great promise for the treatment of cardiac pathologies consequent to cardiomeocyte loss.
Journal ArticleDOI
Metabolic control of YAP and TAZ by the mevalonate pathway
Giovanni Sorrentino,Naomi Ruggeri,Valeria Specchia,Michelangelo Cordenonsi,Miguel Mano,Sirio Dupont,Andrea Manfrin,Eleonora Ingallina,Roberta Sommaggio,Silvano Piazza,Antonio Rosato,Stefano Piccolo,Giannino Del Sal +12 more
TL;DR: It is shown that YAP/TAZ activity is controlled by the SREBP/mevalonate pathway, which is required for proliferation and self-renewal of breast cancer cells and reveals an additional layer of YAP-TAZ regulation by metabolic cues.
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Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems
TL;DR: The current knowledge of the mechanisms responsible for the cellular uptake of cell-penetrating peptides, including the S413-PV peptide, are discussed, and the potential of peptide-based formulations to mediate nucleic acid delivery is discussed.
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A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
Javier E. Girardini,Javier E. Girardini,Marco Napoli,Marco Napoli,Silvano Piazza,Alessandra Rustighi,Alessandra Rustighi,Carolina Marotta,Carolina Marotta,Enrico Radaelli,Valeria Capaci,Valeria Capaci,Lee B. Jordan,Phil Quinlan,Alastair M. Thompson,Alastair M. Thompson,Miguel Mano,Antonio Rosato,Tim Crook,Eugenio Scanziani,Anthony R. Means,Guillermina Lozano,Claudio Schneider,Claudio Schneider,Giannino Del Sal,Giannino Del Sal +25 more
TL;DR: A Pin1/mutant p53 axis that conveys oncogenic signals to promote aggressiveness in human cancers is defined and a transcriptional signature associated with poor prognosis in breast cancer and Pin1 overexpression influenced the prognostic value of p53 mutation is identified.
Journal ArticleDOI
Cationic liposomes for gene delivery.
Sérgio Simões,Ana da Silva Filipe,Henrique Faneca,Miguel Mano,Nuno Penacho,Nejat Düzgüneş,Maria C. Pedroso de Lima +6 more
TL;DR: This review will focus on various parameters governing lipoplex biological activity, from their mode of formation to invivo behaviour, in an attempt to dissect the different barriers that need to be surpassed for efficient gene expression to occur.