L
Lorenzo Del Castello
Researcher at Sapienza University of Rome
Publications - 36
Citations - 1822
Lorenzo Del Castello is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Endothelial dysfunction & Turbulence. The author has an hindex of 19, co-authored 36 publications receiving 1462 citations. Previous affiliations of Lorenzo Del Castello include Eindhoven University of Technology.
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Journal ArticleDOI
Information transfer and behavioural inertia in starling flocks.
Alessandro Attanasi,Andrea Cavagna,Lorenzo Del Castello,Irene Giardina,Tomás S. Grigera,Tomás S. Grigera,Asla Jelic,Stefania Melillo,Leonardo Parisi,Oliver Pohl,Edward Shen,Massimiliano Viale +11 more
TL;DR: It is found that information about direction changes propagates across the flock with a linear dispersion law and negligible attenuation, hence minimizing group decoherence and suggesting that swift decision-making may be the adaptive drive for the strong behavioural polarization observed in many living groups.
Journal ArticleDOI
Collective Behaviour without Collective Order in Wild Swarms of Midges
Alessandro Attanasi,Andrea Cavagna,Lorenzo Del Castello,Irene Giardina,Stefania Melillo,Leonardo Parisi,Oliver Pohl,Bruno Rossaro,Edward Shen,Edmondo Silvestri,Massimiliano Viale +10 more
TL;DR: It is found that correlation increases sharply with the swarm's density, indicating that the interaction between midges is based on a metric perception mechanism, suggesting that correlation, rather than order, is the true hallmark of collective behaviour in biological systems.
Journal ArticleDOI
Finite-Size Scaling as a Way to Probe Near-Criticality in Natural Swarms
Alessandro Attanasi,Andrea Cavagna,Lorenzo Del Castello,Irene Giardina,Stefania Melillo,Leonardo Parisi,Oliver Pohl,Bruno Rossaro,Edward Shen,Edmondo Silvestri,Massimiliano Viale +10 more
TL;DR: By gathering three-dimensional data on swarms of midges in the field, it is found that swarms tune their control parameter and size so as to maintain a scaling behavior of the correlation function, and correlation length and susceptibility scale with the system's size and swarms exhibit a near-maximal degree of correlation at all sizes.
Journal ArticleDOI
Impact of Glycemic Variability on Chromatin Remodeling, Oxidative Stress, and Endothelial Dysfunction in Patients With Type 2 Diabetes and With Target HbA1c Levels.
Sarah Costantino,Francesco Paneni,Francesco Paneni,Rodolfo Battista,Lorenzo Del Castello,Giuliana Capretti,Sergio Chiandotto,Luigi Tanese,Giulio Russo,Dario Pitocco,Gaetano Antonio Lanza,Massimo Volpe,Thomas F. Lüscher,Francesco Cosentino +13 more
TL;DR: In this article, the authors investigated whether epigenetic regulation of the adaptor protein p66Shc, a key driver of mitochondrial oxidative stress, contributes to persistent vascular dysfunction in patients with T2D despite IGC.
Journal ArticleDOI
Adverse epigenetic signatures by histone methyltransferase Set7 contribute to vascular dysfunction in patients with type 2 diabetes mellitus.
Francesco Paneni,Sarah Costantino,Rodolfo Battista,Lorenzo Del Castello,Giuliana Capretti,Sergio Chiandotto,Giuseppe Scavone,Angelo Villano,Dario Pitocco,Gaetano Antonio Lanza,Massimo Volpe,Thomas F. Lüscher,Francesco Cosentino +12 more
TL;DR: In human aortic endothelial cells, silencing of Set7 prevented monomethylation of lysine 4 of histone 3 and abolished NF-kB-dependent oxidant and inflammatory signaling, and this chromatin-modifying enzyme may represent a novel therapeutic approach to prevent atherosclerotic vascular disease in this setting.