L
Loretta Y.Y. Chan
Researcher at University of Hong Kong
Publications - 77
Citations - 3670
Loretta Y.Y. Chan is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Mesangial cell & Kidney. The author has an hindex of 32, co-authored 75 publications receiving 3260 citations. Previous affiliations of Loretta Y.Y. Chan include United Christian Hospital.
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Journal ArticleDOI
Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy
Miao Lin,Wai Han Yiu,Haojia Wu,Loretta Y.Y. Chan,Joseph Leung,WS Au,Kwok Wah Chan,Kar Neng Lai,Sydney C.W. Tang +8 more
TL;DR: Exposure to streptozotocin-induced diabetic and uninephrectomized TLR4-deficient mice had significantly less albuminuria, renal dysfunction, renal cortical NF-κB activation, tubular CCL-2 expression, and interstitial macrophage infiltration than wild-type animals.
Journal ArticleDOI
Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo
Sydney C.W. Tang,Joseph Leung,Katsushige Abe,Kwok Wah Chan,Loretta Y.Y. Chan,Tak Mao Chan,Kar Neng Lai +6 more
TL;DR: In conclusion, albumin is a strong stimulus for tubular IL-8 expression, which occurs via NF-kappaB-dependent pathways through PKC activation and ROS generation.
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Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential
Alice M.S. Cheung,Thomas S.K. Wan,J C K Leung,Loretta Y.Y. Chan,H Huang,YL Kwong,Rhs Liang,Anskar Y.H. Leung +7 more
TL;DR: It is hypothesized that SSCloALDHbr cells in ALDH+AML might denote primitive LSC and confer an inferior prognosis in patients and was significantly associated with adverse cytogenetic abnormalities.
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Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy
Sydney C.W. Tang,Joseph Leung,Joseph Leung,Loretta Y.Y. Chan,Loretta Y.Y. Chan,Yun Hoi Lui,Yun Hoi Lui,Colin S.O. Tang,Colin S.O. Tang,Chi Hang Kan,Chi Hang Kan,Yiu Wing Ho,Yiu Wing Ho,Kar Neng Lai,Kar Neng Lai +14 more
TL;DR: In selected patients with IgAN, MMF is effective in lowering proteinuria and ameliorating some of the putative pathogenetic abnormalities.
Journal ArticleDOI
Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy
Kar Neng Lai,Joseph Leung,Loretta Y.Y. Chan,Moin A. Saleem,Peter W. Mathieson,Ka Ying Tam,Jing Xiao,Fernand Mac-Moune Lai,Sydney C.W. Tang +8 more
TL;DR: In vitro experiments implicates that humoral factors released from mesangial cells are likely to alter the glomerular permeability in the event of proteinuria and tubulointerstitial injury in IgAN.