M
Moin A. Saleem
Researcher at University of Bristol
Publications - 300
Citations - 16427
Moin A. Saleem is an academic researcher from University of Bristol. The author has contributed to research in topics: Podocyte & Nephrin. The author has an hindex of 67, co-authored 278 publications receiving 14407 citations. Previous affiliations of Moin A. Saleem include The Feinstein Institute for Medical Research & National Institute for Health Research.
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Journal ArticleDOI
A Conditionally Immortalized Human Podocyte Cell Line Demonstrating Nephrin and Podocin Expression
Moin A. Saleem,Michael J O'Hare,Jochen Reiser,Richard J M Coward,Carol Inward,Timothy Farren,Chang Ying Xing,Lan Ni,Peter W. Mathieson,Peter Mundel +9 more
TL;DR: The development of this conditionally immortalized human podocyte cell line provides a new tool in the study of podocyte biology, which will enable accurate assessment of the behavior of these complex cells in health and disease.
Journal ArticleDOI
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis
Changli Wei,Shafic El Hindi,Jing Li,Alessia Fornoni,Nelson Goes,Junichiro Sageshima,Dony Maiguel,S. Ananth Karumanchi,Hui-Kim Yap,Moin A. Saleem,Qing-Yin Zhang,Boris Nikolic,Abanti Chaudhuri,Pirouz Daftarian,Eduardo Salido,Armando Torres,Moro O. Salifu,Minnie M. Sarwal,Franz Schaefer,Christian Morath,Vedat Schwenger,Martin Zeier,Vineet Gupta,David M. Roth,Maria Pia Rastaldi,George W. Burke,Phillip Ruiz,Jochen Reiser +27 more
TL;DR: It is reported that serum soluble urokinase receptor (suPAR) is elevated in two-thirds of subjects with primary FSGS, but not in people with other glomerular diseases, and that a higher concentration of suPAR before transplantation underlies an increased risk for recurrence of FSGS after transplantation.
Journal ArticleDOI
Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin
Karin Schwarz,Matias Simons,Jochen Reiser,Moin A. Saleem,Christian Faul,Wihelm Kriz,Andrey S. Shaw,Lawrence B. Holzman,Peter Mundel +8 more
TL;DR: It is shown, by immunoelectron microscopy, that podocin localizes to the podocyte foot process membrane, at the insertion site of the slit diaphragm, and it is postulate thatpodocin serves in the structural organization of the slat diaphagm and the regulation of its filtration function.
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Insulin signaling to the glomerular podocyte is critical for normal kidney function
Gavin I. Welsh,Lorna J Hale,Vera Eremina,Marie Jeansson,Yoshiro Maezawa,Rachel Lennon,Deborah A Pons,Rachel J Owen,Simon C. Satchell,Mervyn J Miles,Christopher J. Caunt,Craig A. McArdle,Hermann Pavenstädt,Jeremy M. Tavaré,Andrew M. Herzenberg,C. Ronald Kahn,Peter W Mathieson,Susan E. Quaggin,Moin A. Saleem,Richard J M Coward,Richard J M Coward +20 more
TL;DR: Examination of "normal" insulin-responsive podocytes in vivo and in vitro demonstrates that insulin signals through the MAPK and PI3K pathways via the insulin receptor and directly remodels the actin cytoskeleton of this cell.
Journal ArticleDOI
Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
Dawid G. Nowak,Jeanette Woolard,Elianna M. Amin,Olga Konopatskaya,Moin A. Saleem,Amanda J. Churchill,Michael Ladomery,Steven J. Harper,David O. Bates +8 more
TL;DR: Regulation of splicing by growth and splice factors is identified as a key event in determining the relative pro-versus anti-angiogenic expression of VEGF isoforms, and it is suggested that p38 MAPK-Clk/sty kinases are responsible for the TGFβ1-induced DSS selection.