L
Lorna S. Ehrlich
Researcher at Stony Brook University
Publications - 30
Citations - 1632
Lorna S. Ehrlich is an academic researcher from Stony Brook University. The author has contributed to research in topics: ESCRT & Capsid. The author has an hindex of 19, co-authored 30 publications receiving 1551 citations. Previous affiliations of Lorna S. Ehrlich include State University of New York System.
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Journal ArticleDOI
Crystal structure of dimeric HIV-1 capsid protein.
Cory Momany,Ladislau C. Kovari,Andrew J. Prongay,Andrew J. Prongay,Walter Keller,Walter Keller,Rossitza K. Gitti,Brian M. Lee,Alexander E. Gorbalenya,Alexander E. Gorbalenya,Liang Tong,Liang Tong,Jan McClure,Lorna S. Ehrlich,Michael F. Summers,Carol A. Carter,Michael G. Rossmann +16 more
TL;DR: X-ray diffraction analysis of a human immunodeficiency virus (HIV-1) capsid (CA) protein shows that each monomer within the dimer consists of seven α-helices, five of which are arranged in a coiled coil-like structure.
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Assembly of recombinant human immunodeficiency virus type 1 capsid protein in vitro.
TL;DR: The observation that assembly and disassembly of purified HIV type 1 CA protein can be induced in vitro suggests an approach for identifying possible control mechanisms involved in HIV viral core assembly.
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Cell Biology of HIV-1 Infection of Macrophages
Carol A. Carter,Lorna S. Ehrlich +1 more
TL;DR: Evidence supporting and refuting the canonical hypothesis of HIV infection of macrophages is examined and recently identified cellular factors that may contribute to the unique aspects of the HIV-macrophage interaction are highlighted.
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HIV-1 Capsid Protein Forms Spherical (Immature-Like) and Tubular (Mature-Like) Particles in Vitro: Structure Switching by pH-induced Conformational Changes
TL;DR: The ability of the CA protein to form a spherical structure that is detectable by DLS but not by electron microscopy indicates that some assemblages are inherently sensitive to perturbation.
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Tsg101 Control of Human Immunodeficiency Virus Type 1 Gag Trafficking and Release
TL;DR: The results demonstrate that Gag associates with endosomal trafficking compartments and indicate that efficient release of virus particles from the plasma membrane requires both the PTAP- and Ub-binding functions of Tsg101 to recruit the cellular machinery required for budding.