B
Brian M. Lee
Researcher at Iowa State University
Publications - 25
Citations - 2910
Brian M. Lee is an academic researcher from Iowa State University. The author has contributed to research in topics: Zinc finger & RNA. The author has an hindex of 16, co-authored 21 publications receiving 2698 citations. Previous affiliations of Brian M. Lee include University of Maryland, Baltimore County & Scripps Research Institute.
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Journal ArticleDOI
Zinc finger proteins: new insights into structural and functional diversity.
TL;DR: Structures have recently been reported for many new zinc finger domains with novel topologies, providing important insights into structure/function relationships and into mechanisms of DNA binding and to a better understanding of their broader functions in transcriptional regulation.
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Structure of the Amino-Terminal Core Domain of the HIV-1 Capsid Protein
Rossitza K. Gitti,Brian M. Lee,Jill Walker,Michael F. Summers,Sanghee Yoo,Wesley I. Sundquist +5 more
TL;DR: The three-dimensional structure of the amino-terminal core domain (residues 1 through 151) of the human immunodeficiency virus-type 1 (HIV-1) capsid protein has been solved by multidimensional heteronuclear magnetic resonance spectroscopy.
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Crystal structure of dimeric HIV-1 capsid protein.
Cory Momany,Ladislau C. Kovari,Andrew J. Prongay,Andrew J. Prongay,Walter Keller,Walter Keller,Rossitza K. Gitti,Brian M. Lee,Alexander E. Gorbalenya,Alexander E. Gorbalenya,Liang Tong,Liang Tong,Jan McClure,Lorna S. Ehrlich,Michael F. Summers,Carol A. Carter,Michael G. Rossmann +16 more
TL;DR: X-ray diffraction analysis of a human immunodeficiency virus (HIV-1) capsid (CA) protein shows that each monomer within the dimer consists of seven α-helices, five of which are arranged in a coiled coil-like structure.
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Dynamical behavior of the hiv-1 nucleocapsid protein
TL;DR: In this paper, the authors collected multidimensional NMR data for the recombinant, isotopically labeled HIV-1 NC protein, and confirmed the presence of weak interknuckle NOEs.
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Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3
A. Martin-Gallardo,W. R. McCombie,Jeannine D. Gocayne,Michael G. FitzGerald,S. Wallace,Brian M. Lee,Jane Lamerdin,S Trapp,Jenny M. Kelley,Luyang Liu,Mark Dubnick,Leslie Johnston-Dow,Anthony R. Kerlavage,P. De Jong,Anthony V. Carrano,Chris Fields,J. C. Venter +16 more
TL;DR: A total of 116, 118 basepairs derived from three cosmids spanning the ERCC1 locus of human chromosome 19q13.3 have been sequenced with automated fluorescence-based sequencers and analysed by polymerase chain reaction amplification and computer methods.