L
Lorraine N. Clark
Researcher at University of Manchester
Publications - 5
Citations - 1169
Lorraine N. Clark is an academic researcher from University of Manchester. The author has contributed to research in topics: Facioscapulohumeral muscular dystrophy & Variable number tandem repeat. The author has an hindex of 5, co-authored 5 publications receiving 1118 citations. Previous affiliations of Lorraine N. Clark include Imperial College London.
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Journal ArticleDOI
Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy.
Cisca Wijmenga,Jane E. Hewitt,Lodewijk A. Sandkuijl,Lorraine N. Clark,Tracy J. Wright,Hans G. Dauwerse,Anne-Marie Gruter,Marten H. Hofker,Petra Moerer,Robert Williamson,Gert-Jan B. van Ommen,George W. Padberg,Rune R. Frants +12 more
TL;DR: Observations indicate that FSHD is caused by independent de novo DNA rearrangements in the EcoRI fragment detected by p13E–11, and in 10 Dutch families analysed, a specific shorter fragment between 14–28 kb co–segregates with FSHd.
Journal ArticleDOI
Analysis of the tandem repeat locus D4Z4 associated with facioscapulohumeral muscular dystrophy.
Jane E. Hewitt,Jane E. Hewitt,Robert Lyle,Lorraine N. Clark,Elizabeth M.A. Valleley,Tracy J. Wright,Cisca Wijmenga,Judith C.T. van Deutekom,Fiona Francis,Paul T. Sharpe,Marten H. Hofker,Rune R. Frants,Robert Williamson +12 more
TL;DR: Southern blotting, FISH and isolation of cDNA and genomic clones are shown to show that there are repeat sequences similar to D4Z4 at other locations in the human genome, and it is postulate that deletion of D4z4 sequences could produce a position effect.
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The FSHD-associated repeat, D4Z4, is a member of a dispersed family of homeobox-containing repeats, subsets of which are clustered on the short arms of the acrocentric chromosomes
TL;DR: The isolation of two YAC clones that map to chromosome 14 and that contain multiple copies of a D4Z4-like repeat is described and the name 3.3-kb repeat is proposed for this family of repetitive sequence elements.
Journal ArticleDOI
Structure and sequence of the human homeobox gene HOX7
TL;DR: A cosmid containing the human sequence HOX7, homologous to the murine Hox-7 gene, was isolated from a genomic library, and the positions of the coding sequences were determined by hybridization.
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Analysis of the organisation and localisation of the FSHD-associated tandem array in primates: implications for the origin and evolution of the 3.3 kb repeat family.
TL;DR: The finding that tandem arrays closely related to D4Z4 have been maintained at loci homologous to human chromosome 4q35-qter in apes and Old World monkeys suggests a functionally important role for these sequences.