G
George W. Padberg
Researcher at Radboud University Nijmegen
Publications - 173
Citations - 14556
George W. Padberg is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Facioscapulohumeral muscular dystrophy & Muscular dystrophy. The author has an hindex of 61, co-authored 171 publications receiving 13474 citations. Previous affiliations of George W. Padberg include Leiden University Medical Center & Radboud University Nijmegen Medical Centre.
Papers
More filters
Journal ArticleDOI
Treatment of single brain metastasis: Radiotherapy alone or combined with neurosurgery
Charles J. Vecht,H. Haaxma-Reiche,Evert M. Noordijk,George W. Padberg,J. H. C. Voormolen,F. H. Hoekstra,J. T. J. Tans,N. Lambooij,J. A. L. Metsaars,A. R. Wattendorff,Ronald Brand,Jo Hermans +11 more
TL;DR: It is coclude that patients with single brain metastasis and stable extracranial tumor activity should be treated with surgical excision and radiotherapy, and that radiotherapy alone appears to be sufficient.
Journal ArticleDOI
A Unifying Genetic Model for Facioscapulohumeral Muscular Dystrophy
Richard J.L.F. Lemmers,Patrick J. van der Vliet,Rinse Klooster,Sabrina Sacconi,Pilar Camaño,Johannes G. Dauwerse,Lauren Snider,Kirsten R. Straasheijm,Gert-Jan B. van Ommen,George W. Padberg,Daniel G. Miller,Stephen J. Tapscott,Rabi Tawil,Rune R. Frants,Silvère M. van der Maarel +14 more
TL;DR: It is shown that FSHD patients carry specific single-nucleotide polymorphisms in the chromosomal region distal to the last D4Z4 repeat that creates a canonical polyadenylation signal for transcripts derived from DUX4, a double homeobox gene of unknown function that straddles the last repeat unit and the adjacent sequence.
Journal ArticleDOI
Localization of the gene for Cowden disease to chromosome 10q22-23
Marcel R. Nelen,George W. Padberg,E. A. J. Peeters,Albert Y. Lin,B. Van Den Helm,Rune R. Frants,Valérie Coulon,Alisa M. Goldstein,M.M.M. van Reen,Douglas F. Easton,Rosalind A. Eeles,Shirley Hodgson,John J. Mulvihill,Victoria Murday,Monica Tucker,E.C.M. Mariman,T. M. Starink,Bruce Ponder,Hans-Hilger Ropers,Hannie Kremer,Michel Longy,Charis Eng,Charis Eng +22 more
TL;DR: Cowden disease (CD) (MIM 158350), or multiple hamartoma syndrome, is a rare autosomal dominant familial cancer syndrome with a high risk of breast cancer and central nervous system manifestations of CD were emphasized only recently.
Journal ArticleDOI
The choice of treatment of single brain metastasis should be based on extracranial tumor-activity and age
Evert M. Noordijk,Charles J. Vecht,H. Haaxma-Reiche,George W. Padberg,J. H. C. Voormolen,F. H. Hoekstra,J. T. J. Tans,N. Lambooij,J. A. L. Metsaars,A. R. Wattendorff,Ronald Brand,Jo Hermans +11 more
TL;DR: For patients with single brain metastasis and with controlled or absent extracranial tumor activity, radiotherapy alone seems to be sufficient and should be considered for patients in a good performance status with surgically unaccessible single metastasis or even with multiple brain metastases.
Journal ArticleDOI
Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy.
Cisca Wijmenga,Jane E. Hewitt,Lodewijk A. Sandkuijl,Lorraine N. Clark,Tracy J. Wright,Hans G. Dauwerse,Anne-Marie Gruter,Marten H. Hofker,Petra Moerer,Robert Williamson,Gert-Jan B. van Ommen,George W. Padberg,Rune R. Frants +12 more
TL;DR: Observations indicate that FSHD is caused by independent de novo DNA rearrangements in the EcoRI fragment detected by p13E–11, and in 10 Dutch families analysed, a specific shorter fragment between 14–28 kb co–segregates with FSHd.