L
Louis J. Ignarro
Researcher at University of California, Los Angeles
Publications - 335
Citations - 47353
Louis J. Ignarro is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Nitric oxide & Nitric oxide synthase. The author has an hindex of 106, co-authored 335 publications receiving 46008 citations. Previous affiliations of Louis J. Ignarro include Boston University & Konkuk University.
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Journal ArticleDOI
Activation of hepatic guanylate cyclase by nitrosyl-heme complexes. Comparison of unpurified and partially purified enzyme.
James C. Edwards,Barbara K. Barry,Darlene Y. Gruetter,Eliot H. Ohlstein,William H. Baricos,Louis J. Ignarro +5 more
TL;DR: The data indicate that the effects of these diverse agents on guanylate cyclase activation by preformed NO-heme are similar to their effects on enzyme activation by NO and nitroso compounds, both of which readily form NO- heme complexes.
Journal Article
The cloned neurotensin receptor mediates cyclic GMP formation when coexpressed with nitric oxide synthase cDNA.
B S Slusher,A E Zacco,J A Maslanski,T E Norris,M W McLane,W C Moore,N E Rogers,Louis J. Ignarro +7 more
TL;DR: Rat neurotensin receptor (NT) receptor (NTR) cDNA was subcloned into the pRC-CMV expression vector and transfected into 293 cells, and cellular clones that stably expressed the NTR were isolated and characterized, giving the first report of NT mediating cGMP formation with a cloned receptor and the first evidence that NT-induced cG MP accumulation requires the production of nitric oxide.
Journal ArticleDOI
Inhibitors of Nitric Oxide Promote Microvascular Thrombosis
Babak Azizzadeh,Georgette M. Buga,Gerald S. Berke,Babak Larian,Louis J. Ignarro,Keith E. Blackwell +5 more
TL;DR: Nitric oxide plays a role in microvascular anastamotic thrombosis in New Zealand white rabbits using an in vivo rabbit model and intravenous NO inhibitors appear to increase the short-term rate ofmicrovascular thromBosis.
Journal ArticleDOI
Cell density-enhanced expression of inducible nitric oxide synthase in murine macrophages mediated by interferon-β
Aaron T. Jacobs,Louis J. Ignarro +1 more
TL;DR: Considering the importance of NO as a cytotoxic mediator of host immunity, the data suggest that macrophage density is important in regulating the magnitude of NO production, and thus, the host response to infection.