L
Louis J. Ignarro
Researcher at University of California, Los Angeles
Publications - 335
Citations - 47353
Louis J. Ignarro is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Nitric oxide & Nitric oxide synthase. The author has an hindex of 106, co-authored 335 publications receiving 46008 citations. Previous affiliations of Louis J. Ignarro include Boston University & Konkuk University.
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Pyrrolidine Dithiocarbamate Inhibits Induction of Nitric Oxide Synthase Activity in Rat Alveolar Macrophages
TL;DR: Findings suggest iNOS activity in macrophages treated with LPS + IFN gamma requires NF-kappa B activation, and Pyrrolidine dithiocarbamate added to cultured macrophage stimulated with lipopolysaccharide and interferon-gamma suggests this requirement.
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Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor release
TL;DR: A previously unrecognized contribution of platelets to the regulation of gastric ulcer healing is demonstrated, mediated through the release from platelets of endostatin and possibly VEGF.
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Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.
TL;DR: Observations indicate that free NO is formed as a result of NOS-catalyzed L-arginine oxidation and that SOD enhances the generation of NO without directly affecting NO itself.
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Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins.
TL;DR: No and nitroso compounds may react with enzyme-bound heme to generate a modified porphyrin which structurally resembles protoporphyr in IX in its interaction with guanylate cyclase.
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Haem‐Dependent Activation of Guanylate Cyclase and Cyclic GMP Formation by Endogenous Nitric Oxide: A Unique Transduction Mechanism for Transcellular Signaling
TL;DR: This intercellular or transcellular signaling mechanism permits the rapid initiation of localized complementary cellular functions leading to increased local blood flow, inhibition of local thrombosis, and modulation of phagocytosis and cytotoxicity.