Louis Malspeis

TL;DR: In consideration of the potential for acute hepatotoxic reactions to GM, as well as to the other benzoquinoid ansamycins based upon structural analogy, additional pharmacological and therapeutic information is required to ascertain whether these compounds are viable candidates for clinical development.

TL;DR: Halichondrin B was compared with other agents which interfere with the binding of vinca alkaloids to tubulin in terms of its effects on tubulin polymerization, inhibition of GTP hydrolysis, inhibited of nucleotide exchange, and stabilization of tubulin, as well as the quantitative assessment of its effect on vincA alkaloid binding and inhibition of cell growth.

TL;DR: Results of experimentation to date demonstrate that a hollow fiber encapsulation/implantation methodology provides quantitative indices of drug efficacy with minimum expenditures of time and materials.

TL;DR: Nontoxic disulfide-substituted benzamides were identified that attack the zinc fingers, inactivate cell-free virions, inhibit acute and chronic infections, and exhibit broad antiretroviral activity.

TL;DR: Data generated in the new National Cancer Institute drug evaluation program, which are based on inhibition of cell growth in 60 human tumor cell lines, were probed with nine known antimitotic agents using the COMPARE algorithm to have great promise for the identification of new antimitosis agents with antineoplastic potential.