L
Louisa E. Jeffery
Researcher at University of Birmingham
Publications - 32
Citations - 3311
Louisa E. Jeffery is an academic researcher from University of Birmingham. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 17, co-authored 31 publications receiving 2639 citations. Previous affiliations of Louisa E. Jeffery include National Institute for Health Research.
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Journal ArticleDOI
Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4
Omar S. Qureshi,Yong Zheng,Kyoko Nakamura,Kesley Attridge,Claire N. Manzotti,Emily M. Schmidt,Jennifer Baker,Louisa E. Jeffery,Satdip Kaur,Zoe Briggs,Tie Z. Hou,Clare E. Futter,Graham Anderson,Lucy S. K. Walker,David M. Sansom +14 more
TL;DR: A mechanism of immune regulation in which CTLA-4 acts as an effector molecule to inhibit CD28 costimulation by the cell-extrinsic depletion of ligands is revealed, accounting for many of the known features of the CD28–CTLA- 4 system.
Journal ArticleDOI
1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3
Louisa E. Jeffery,Fiona Burke,Manuela Mura,Yong Zheng,Omar S. Qureshi,Martin Hewison,Lucy S. K. Walker,David A. Lammas,Karim Raza,David M. Sansom +9 more
TL;DR: The results suggest that 1,25(OH)2D3 and IL-2 have direct synergistic effects on activated T cells, acting as potent anti-inflammatory agents and physiologic inducers of adaptive regulatory T cells.
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Th17 plasticity and its relevance to inflammatory bowel disease
TL;DR: New data from mouse models of IBD suggest that T cell plasticity, particularly along the Th1-Th17 and Th17-Treg axes, plays an important role in the regulation of intestinal immune responses and patients with IBD demonstrate increased numbers of "transdifferentiated" T cell populations suggestive of heightened plasticity.
Journal ArticleDOI
Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.
Louisa E. Jeffery,Alice M. Wood,Omar S. Qureshi,Tie Zheng Hou,David G. Gardner,Zoe Briggs,Satdip Kaur,Karim Raza,Karim Raza,David M. Sansom +9 more
TL;DR: In this article, it was shown that the presence of inactive 1,25-Dihydroxyvitamin D(3)-1α-hydroxylase (CYP27B1) is sufficient to alter T cell responses only when dendritic cells are present.
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Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation
Omar S. Qureshi,Satdip Kaur,Tie Zheng Hou,Louisa E. Jeffery,Natalie S. Poulter,Zoe Briggs,Rupert Kenefeck,Anna K. Willox,Stephen J. Royle,Joshua Z. Rappoport,David M. Sansom +10 more
TL;DR: The data support a model of trafficking whereby CTLA-4 is constitutively internalized in a ligand-independent manner undergoing both recycling and degradation, and emphasize the importance of clathrin-mediated endocytosis in regulating CTla-4 trafficking throughout T cell activation.