T
Taku Kobayashi
Researcher at Kitasato University
Publications - 164
Citations - 5457
Taku Kobayashi is an academic researcher from Kitasato University. The author has contributed to research in topics: Ulcerative colitis & Inflammatory bowel disease. The author has an hindex of 31, co-authored 132 publications receiving 4121 citations. Previous affiliations of Taku Kobayashi include University of North Carolina at Chapel Hill & KEK.
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Journal ArticleDOI
Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis
Nobuhiko Kamada,Tadakazu Hisamatsu,Susumu Okamoto,Hiroshi Chinen,Taku Kobayashi,Toshiro Sato,Atsushi Sakuraba,Mina T. Kitazume,Akira Sugita,Kazutaka Koganei,Kiyoko S. Akagawa,Toshifumi Hibi +11 more
TL;DR: Data suggest that this IL-23/IFN-gamma-positive feedback loop induced by abnormal intestinal macrophages contributes to the pathogenesis of chronic intestinal inflammation in patients with CD.
Journal ArticleDOI
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease
Taku Kobayashi,Susumu Okamoto,Tadakazu Hisamatsu,Nobuhiko Kamada,Hiroshi Chinen,Riko Saito,Mina T. Kitazume,Atsushi Nakazawa,Akira Sugita,Kazutaka Koganei,Ken-ichi Isobe,Toshifumi Hibi +11 more
TL;DR: IL23 may play important roles in controlling the differential Th1/Th17 balance in both UC and CD, although Th17 cells may exist in both diseases.
Journal ArticleDOI
Evidence-based clinical practice guidelines for inflammatory bowel disease
Katsuyoshi Matsuoka,Taku Kobayashi,Fumiaki Ueno,Toshiyuki Matsui,Fumihito Hirai,Nagamu Inoue,Jun Kato,Kenji Kobayashi,Kiyonori Kobayashi,Kazutaka Koganei,Reiko Kunisaki,Satoshi Motoya,Masakazu Nagahori,Hiroshi Nakase,Fumio Omata,Masayuki Saruta,Toshiaki Watanabe,Toshiaki Tanaka,Takanori Kanai,Yoshinori Noguchi,Ken Ichi Takahashi,Kenji Watanabe,Toshifumi Hibi,Yasuo Suzuki,Mamoru Watanabe,Kentaro Sugano,Tooru Shimosegawa +26 more
TL;DR: This English version was produced and edited based on the existing updated guidelines for ulcerative colitis and Crohn’s disease in Japanese, developed with the basic concept of the Grading of Recommendations Assessment, Development, and Evaluation system.
Journal ArticleDOI
An indirect search for weakly interacting massive particles in the sun using 3109.6 days of upward-going muons in super-kamiokande
Tetsuya S. Tanaka,K. Abe,K. Abe,Y. Hayato,Y. Hayato,T. Iida,J. Kameda,J. Kameda,Yusuke Koshio,Yusuke Koshio,Y. Kouzuma,M. Miura,M. Miura,S. Moriyama,S. Moriyama,Masayuki Nakahata,Masayuki Nakahata,S. Nakayama,S. Nakayama,Y. Obayashi,Y. Obayashi,Hiroyuki Sekiya,Hiroyuki Sekiya,Masato Shiozawa,Masato Shiozawa,Yasunari Suzuki,Yasunari Suzuki,Atsushi Takeda,Atsushi Takeda,Y. Takenaga,Koh Ueno,K. Ueshima,S. Yamada,Tsutomu Yokozawa,C. Ishihara,S. Hazama,H. Kaji,Takaaki Kajita,Takaaki Kajita,K. Kaneyuki,K. Kaneyuki,T. McLachlan,Ko Okumura,Yasuhiro Shimizu,N. Tanimoto,Frédéric Dufour,E. Kearns,E. Kearns,Michael Litos,J. L. Raaf,J. L. Stone,J. L. Stone,L. R. Sulak,J. P. Cravens,K. Bays,W. R. Kropp,S. Mine,C. Regis,M. B. Smy,M. B. Smy,H. W. Sobel,H. W. Sobel,K. S. Ganezer,John Hill,W. E. Keig,J. S. Jang,J. Y. Kim,I. T. Lim,Justin Albert,Kate Scholberg,Kate Scholberg,C. W. Walter,C. W. Walter,R. A. Wendell,T. Wongjirad,T. Ishizuka,Shigeki Tasaka,J. G. Learned,S. Matsuno,S. N. Smith,K. Martens,M. R. Vagins,M. R. Vagins,Y. Watanabe,T. Hasegawa,T. Ishida,T. Ishii,Taku Kobayashi,T. Nakadaira,K. Nakamura,K. Nakamura,K. Nishikawa,H. Nishino,Yuichi Oyama,K. Sakashita,T. Sekiguchi,T. Tsukamoto,A. T. Suzuki,Y. Takeuchi,Y. Takeuchi,M. Ikeda,A. Minamino,Tsuyoshi Nakaya,Tsuyoshi Nakaya,L. Labarga,Y. Fukuda,Yoshitaka Itow,G. Mitsuka,C. K. Jung,C. McGrew,G. Lopez,C. Yanagisawa,N. Tamura,Hirokazu Ishino,A. Kibayashi,Makoto Sakuda,Y. Kuno,Minoru Yoshida,S. B. Kim,B. S. Yang,H. Okazawa,Y. Choi,K. Nishijima,Y. Yokosawa,M. Koshiba,Y. Totsuka,Masashi Yokoyama,Song Chen,Y. Heng,Zishuo Yang,Huaqiao Zhang,D. Kielczewska,P. Mijakowski,K. Connolly,M. Dziomba,E. Thrane,E. Thrane,R. J. Wilkes +137 more
TL;DR: In this article, an indirect search for high energy neutrinos from Weakly Interacting Massive Particle (WIMP) annihilation in the Sun using upward-going muon (upmu) events at Super-Kamiokande was performed.
Journal ArticleDOI
Th17 plasticity and its relevance to inflammatory bowel disease
TL;DR: New data from mouse models of IBD suggest that T cell plasticity, particularly along the Th1-Th17 and Th17-Treg axes, plays an important role in the regulation of intestinal immune responses and patients with IBD demonstrate increased numbers of "transdifferentiated" T cell populations suggestive of heightened plasticity.