L
Louise Carlson
Researcher at National Institutes of Health
Publications - 18
Citations - 3766
Louise Carlson is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transcription factor & Internal medicine. The author has an hindex of 13, co-authored 15 publications receiving 3669 citations.
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Journal ArticleDOI
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
TL;DR: Results suggest that phosphorylation at one or both of these residues is critical for activation of NF-kappa B, the transcription factor inhibited by I kappa B-alpha.
Journal ArticleDOI
Requirement for NF-κB in osteoclast and B-cell development
Guido Franzoso,Louise Carlson,Lianping Xing,Ljiljana Poljak,Elizabeth W. Shores,Keith Brown,Antonio Leonardi,Tom Tran,Brendan F. Boyce,Ulrich Siebenlist +9 more
TL;DR: It is demonstrated that unlike the respective single knockout mice, the p50/p52 double knockout mice fail to generate mature osteoclasts and B cells, apparently because of defects that track with these lineages in adoptive transfer experiments.
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Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture
Guido Franzoso,Louise Carlson,Ljiljana Poljak,Elizabeth W. Shores,Suzanne L. Epstein,Antonio Leonardi,Alex Grinberg,Tom Tran,Tanya Scharton-Kersten,Miriam R. Anver,Paul E. Love,Keith Brown,Ulrich Siebenlist +12 more
TL;DR: These phenotypes are largely overlapping with those observed in Bcl-3 knockout animals, but distinct from those of p50 knockouts, supporting the notion of a physiologically relevant complex of p52 homodimers and B cl-3.
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Critical Roles for the Bcl-3 Oncoprotein in T Cell–Mediated Immunity, Splenic Microarchitecture, and Germinal Center Reactions
Guido Franzoso,Louise Carlson,Tanya Scharton-Kersten,Elizabeth W. Shores,Suzanne L. Epstein,Alexander Grinberg,Tom Tran,Emily Shacter,Antonio Leonardi,Miriam R. Anver,Paul E. Love,Alan Sher,Ulrich Siebenlist +12 more
TL;DR: Critical roles for Bcl-3 in antigen-specific priming of T and B cells are revealed and altered microarchitecture of secondary lymphoid organs in mutant mice, including partial loss of B cells, may underlie the immunologic defects.
Journal ArticleDOI
NF‐κB p50 and p52 Expression Is Not Required for RANK‐Expressing Osteoclast Progenitor Formation but Is Essential for RANK‐ and Cytokine‐Mediated Osteoclastogenesis
Lianping Xing,Timothy P. Bushnell,Louise Carlson,Zhenxing Tai,Mehrdad Tondravi,Ulrich Siebenlist,Fay Young,Brendan F. Boyce +7 more
TL;DR: NF‐κB p50 and p52 expression is not required for formation of RANK‐expressing osteoclast progenitors but is essential for RANK'S osteocline precursors to differentiate into TRAP+ osteoclasts in response to RANKL and other osteOClastogenic cytokines.