A
Antonio Leonardi
Researcher at University of Naples Federico II
Publications - 98
Citations - 5291
Antonio Leonardi is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Signal transducing adaptor protein & Cancer. The author has an hindex of 34, co-authored 95 publications receiving 4923 citations. Previous affiliations of Antonio Leonardi include University of Udine & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Requirement for NF-κB in osteoclast and B-cell development
Guido Franzoso,Louise Carlson,Lianping Xing,Ljiljana Poljak,Elizabeth W. Shores,Keith Brown,Antonio Leonardi,Tom Tran,Brendan F. Boyce,Ulrich Siebenlist +9 more
TL;DR: It is demonstrated that unlike the respective single knockout mice, the p50/p52 double knockout mice fail to generate mature osteoclasts and B cells, apparently because of defects that track with these lineages in adoptive transfer experiments.
Journal ArticleDOI
Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture
Guido Franzoso,Louise Carlson,Ljiljana Poljak,Elizabeth W. Shores,Suzanne L. Epstein,Antonio Leonardi,Alex Grinberg,Tom Tran,Tanya Scharton-Kersten,Miriam R. Anver,Paul E. Love,Keith Brown,Ulrich Siebenlist +12 more
TL;DR: These phenotypes are largely overlapping with those observed in Bcl-3 knockout animals, but distinct from those of p50 knockouts, supporting the notion of a physiologically relevant complex of p52 homodimers and B cl-3.
Journal ArticleDOI
ABIN-1 Binds to NEMO/IKKγ and Co-operates with A20 in Inhibiting NF-κB
Claudio Mauro,Francesco Pacifico,Alfonso Lavorgna,Stefano Mellone,Alessio Iannetti,Renato Acquaviva,S. Formisano,Pasquale Vito,Antonio Leonardi +8 more
TL;DR: ABIN-1 (A20 binding inhibitor of NF-κB) is identified as a NEMO/IKKγ-interacting protein and physically links A20 to NemO/iKKγ and facilitates A20-mediated de-ubiquitination of NEMo/Ikkγ, thus resulting in inhibition of NF -κB.
Journal ArticleDOI
APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process
Carlo Vascotto,Damiano Fantini,Milena Romanello,Laura Cesaratto,Marta Deganuto,Antonio Leonardi,J. Pablo Radicella,Mark R. Kelley,Chiara D'Ambrosio,Andrea Scaloni,Franco Quadrifoglio,Gianluca Tell +11 more
TL;DR: The data demonstrate that APE1 affects cell growth by directly acting on RNA quality control mechanisms, thus affecting gene expression through posttranscriptional mechanisms.
Journal ArticleDOI
The neutrophil gelatinase-associated lipocalin (NGAL), a NF-κB-regulated gene, is a survival factor for thyroid neoplastic cells
Alessio Iannetti,Francesco Pacifico,Renato Acquaviva,Alfonso Lavorgna,Elvira Crescenzi,Carlo Vascotto,Gianluca Tell,Anna Maria Salzano,Andrea Scaloni,Emilia Vuttariello,Gennaro Chiappetta,S. Formisano,Antonio Leonardi +12 more
TL;DR: The data suggest that NF-κB contributes to thyroid tumor cell survival by controlling iron uptake via NGAL, a protein involved in inflammatory and immune responses, and which is highly expressed in human thyroid carcinomas.