L
Louise Keehn
Researcher at King's College London
Publications - 15
Citations - 325
Louise Keehn is an academic researcher from King's College London. The author has contributed to research in topics: Pulse wave velocity & Blood pressure. The author has an hindex of 7, co-authored 9 publications receiving 210 citations. Previous affiliations of Louise Keehn include St Thomas' Hospital.
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Journal ArticleDOI
Gut microbial diversity is associated with lower arterial stiffness in women
Cristina Menni,Chihung Lin,Marina Cecelja,Massimo Mangino,Maria Luisa Matey-Hernandez,Louise Keehn,Robert P. Mohney,Claire J. Steves,Tim D. Spector,Chang-Fu Kuo,Chang-Fu Kuo,Phil Chowienczyk,Ana M. Valdes,Ana M. Valdes,Ana M. Valdes +14 more
TL;DR: This first human observation linking the gut microbiome to arterial stiffness suggests that targeting the microbiome may be a way to treat arterial ageing, and Gut microbiome diversity is inversely associated with arterials stiffness in women.
Journal ArticleDOI
Altered Dependence of Aortic Pulse Wave Velocity on Transmural Pressure in Hypertension Revealing Structural Change in the Aortic Wall
Nicholas Gaddum,Louise Keehn,Antoine Guilcher,Alberto Gomez,Sally Brett,Philipp Beerbaum,Tobias Schaeffter,Philip Chowienczyk +7 more
TL;DR: The results suggest that hypertension is associated with a profound change in aortic wall mechanical properties possibly because of destruction of elastin leading to less strain-induced stiffening and predisposition to aorta dissection.
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Measurement of pulse wave velocity in children: comparison of volumetric and tonometric sensors, brachial-femoral and carotid-femoral pathways.
TL;DR: Volumetric methods appear reproducible and are easy to use in children, but values obtained by Vicorder and SphygmoCor are not interchangeable even when measured over the same pathway.
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Arterial stiffening is a heritable trait associated with arterial dilation but not wall thickening: a longitudinal study in the twins UK cohort.
Marina Cecelja,Benyu Jiang,Louise Keehn,Tarique Hussain,Miguel Silva Vieira,Alkystis Phinikaridou,Gerald F. Greil,Tim D. Spector,Philip Chowienczyk +8 more
TL;DR: Arterial stiffening, as measured by PWVcf, and dilation are heritable but independent of arterial wall thickening.
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Decreased Arterial Elasticity in Children With Nondialysis Chronic Kidney Disease Is Related to Blood Pressure and Not to Glomerular Filtration Rate
TL;DR: In children with nondialysis chronic kidney disease, changes in elastic properties of the carotid artery are primarily related to BP and not to glomerular renal function.