L
Lu Xu
Researcher at Wuhan University
Publications - 10
Citations - 1129
Lu Xu is an academic researcher from Wuhan University. The author has contributed to research in topics: Tumor hypoxia & Photodynamic therapy. The author has an hindex of 9, co-authored 10 publications receiving 698 citations.
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Journal ArticleDOI
An Adenosine Triphosphate-Responsive Autocatalytic Fenton Nanoparticle for Tumor Ablation with Self-Supplied H2O2 and Acceleration of Fe(III)/Fe(II) Conversion
TL;DR: An adenosine triphosphate-responsive autocatalytic Fenton nanosystem was designed and synthesized for tumor ablation with self-supplied H2O2 and TA-mediated acceleration of Fe(III)/Fe(II) conversion to guarantee efficient Fenton reaction-mediated CDT.
Journal ArticleDOI
Optically-controlled bacterial metabolite for cancer therapy.
Di Wei Zheng,Ying Chen,Zi Hao Li,Lu Xu,Chu Xin Li,Bin Li,Jin Xuan Fan,Si-Xue Cheng,Xian-Zheng Zhang +8 more
TL;DR: The authors combine carbon nitride with nitric oxide generation enzyme-positive E. coli for photo-controlled metabolite therapy (PMT) and observe increased effects both in vitro and in tumor-bearing mice.
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Dual-Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor Based on an O2 Self-Sufficient Nanoplatform
Li-Han Liu,Yao-Hui Zhang,Wen-Xiu Qiu,Lu Zhang,Fan Gao,Bin Li,Lu Xu,Jin-Xian Fan,Zi-Hao Li,Xian-Zheng Zhang +9 more
TL;DR: In vitro and in vivo experiments demonstrate the superior competence of LipoMB/CaO2 to alleviate tumor hypoxia, suppress tumor growth and antitumor metastasis with low side-effect.
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Photocatalyzing CO2 to CO for Enhanced Cancer Therapy
TL;DR: Interestingly, this study finds that HisAgCCN can enhance mitochondria biogenesis and aggravate oxidative stress in cancer cells, whereas protect normal cells from chemotherapy‐induced apoptosis as well.
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Interfering with Lactate-Fueled Respiration for Enhanced Photodynamic Tumor Therapy by a Porphyrinic MOF Nanoplatform
Zhao-Xia Chen,Miao-Deng Liu,Ming-Kang Zhang,Shi-Bo Wang,Lu Xu,Chu-Xin Li,Fan Gao,Bo-Ru Xie,Zhen-Lin Zhong,Xian-Zheng Zhang +9 more
TL;DR: Both in vitro and in vivo studies confirmed good biocompatibility and enhanced PDT efficacy of the HA‐coated PZM nanoparticles (CHC‐PZM@HA) in tumor cells, which will provide a new perspective in cancer therapy.