Lu Yang

TL;DR: In this article, a lysosomal K+ channel complex that is activated by growth factors and gated by protein kinase-B (AKT) was identified as a potential target for Parkinson's disease.

TL;DR: In this paper, the authors examined neural distributions in the mouse, nonhuman primate, and human livers with advanced 3D imaging and found that neural innervations within the liver are predominantly sympathetic, but not parasympathetic, inputs.

TL;DR: This study elucidates the critical function of local sympathetic innervations in negatively modulating the lung innate immune responses and shows that the sympathetic neurotransmitter norepinephrine, or specific agonists of the β2-adrenergic receptor, can inhibit the LPS- or IL-33–elicited immune response in a cell-intrinsic manner.

TL;DR: The ImmuView procedure for whole-tissue 3D assessment of neural innervations in the intact immune organs of adult mice revealed an intricate, panicle-shaped sympathetic architecture in the parenchyma of the spleen but not other immune organs, including the lymph nodes, Peyer's patch, and thymus.

TL;DR: A new BoneClear method is reported here for the robust immunolabeling of different cellular structures in the intact, unsectioned bone tissues of adult mice and compared with the published methods for the wholetissue immunlabeling and 3D imaging of intended cellular structures.