L
Lubna Patrawala
Researcher at University of Texas MD Anderson Cancer Center
Publications - 19
Citations - 6082
Lubna Patrawala is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Progenitor cell & Prostate cancer. The author has an hindex of 14, co-authored 19 publications receiving 5829 citations. Previous affiliations of Lubna Patrawala include University of Texas Health Science Center at Houston & Woodward, Inc..
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Journal ArticleDOI
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
Can Liu,Kevin Kelnar,Bigang Liu,Xin Chen,Tammy Calhoun-Davis,Hangwen Li,Lubna Patrawala,Hong Yan,Collene R. Jeter,Sofia Honorio,Jason F. Wiggins,Andreas G. Bader,Randy Fagin,David F.M. Brown,Dean G. Tang +14 more
TL;DR: This study shows that miR-34a is a key negative regulator of CD44(+) prostate cancer cells and establishes a strong rationale for developing miR -34a as a novel therapeutic agent against prostate CSCs.
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Side Population Is Enriched in Tumorigenic, Stem-Like Cancer Cells, whereas ABCG2+ and ABCG2− Cancer Cells Are Similarly Tumorigenic
Lubna Patrawala,Tammy Calhoun,Robin Schneider-Broussard,Jianjun Zhou,Jianjun Zhou,Kent Claypool,Dean G. Tang +6 more
TL;DR: The results suggest that the side population is enriched with tumorigenic stem-like cancer cells,ABCG2 expression identifies mainly fast-cycling tumor progenitors, and the ABCG2- population contains primitive stem- like cancer cells.
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Highly purified CD44 + prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells
Lubna Patrawala,Tammy Calhoun,Robin Schneider-Broussard,Hangwen Li,Bobby Bhatia,Shao Hua Tang,J. G. Reilly,Dhyan Chandra,Jain Zhou,Kent Claypool,Lezlee G Coghlan,Dean G. Tang +11 more
TL;DR: The results suggest that the CD44+ PCa cell population is enriched in tumorigenic and metastatic progenitor cells.
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Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34
Jason F. Wiggins,Lynnsie Ruffino,Kevin Kelnar,Michael Omotola,Lubna Patrawala,David F.M. Brown,Andreas G. Bader +6 more
TL;DR: The development of a therapeutic formulation using chemically synthesized miR-34a and a lipid-based delivery vehicle that blocks tumor growth in mouse models of non-small-cell lung cancer is described, providing proof of concept for the systemic delivery of a synthetic tumor suppressor mimic.
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The let-7 microRNA reduces tumor growth in mouse models of lung cancer.
Aurora Esquela-Kerscher,Phong Trang,Jason F. Wiggins,Lubna Patrawala,Angie Cheng,Lance P. Ford,Joanne B. Weidhaas,David F.M. Brown,Andreas G. Bader,Frank J. Slack +9 more
TL;DR: In this paper, the authors used both in vitro and in vivo approaches to show that the let-7 microRNA directly represses cancer growth in the lung and indicated that this miRNA may be useful as a novel therapeutic agent in lung cancer.