D
Dean G. Tang
Researcher at Roswell Park Cancer Institute
Publications - 182
Citations - 16295
Dean G. Tang is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Prostate cancer & Cancer stem cell. The author has an hindex of 62, co-authored 173 publications receiving 14704 citations. Previous affiliations of Dean G. Tang include Wayne State University & University College London.
Papers
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Journal ArticleDOI
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
Can Liu,Kevin Kelnar,Bigang Liu,Xin Chen,Tammy Calhoun-Davis,Hangwen Li,Lubna Patrawala,Hong Yan,Collene R. Jeter,Sofia Honorio,Jason F. Wiggins,Andreas G. Bader,Randy Fagin,David F.M. Brown,Dean G. Tang +14 more
TL;DR: This study shows that miR-34a is a key negative regulator of CD44(+) prostate cancer cells and establishes a strong rationale for developing miR -34a as a novel therapeutic agent against prostate CSCs.
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Side Population Is Enriched in Tumorigenic, Stem-Like Cancer Cells, whereas ABCG2+ and ABCG2− Cancer Cells Are Similarly Tumorigenic
Lubna Patrawala,Tammy Calhoun,Robin Schneider-Broussard,Jianjun Zhou,Jianjun Zhou,Kent Claypool,Dean G. Tang +6 more
TL;DR: The results suggest that the side population is enriched with tumorigenic stem-like cancer cells,ABCG2 expression identifies mainly fast-cycling tumor progenitors, and the ABCG2- population contains primitive stem- like cancer cells.
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Highly purified CD44 + prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells
Lubna Patrawala,Tammy Calhoun,Robin Schneider-Broussard,Hangwen Li,Bobby Bhatia,Shao Hua Tang,J. G. Reilly,Dhyan Chandra,Jain Zhou,Kent Claypool,Lezlee G Coghlan,Dean G. Tang +11 more
TL;DR: The results suggest that the CD44+ PCa cell population is enriched in tumorigenic and metastatic progenitor cells.
Journal ArticleDOI
Understanding cancer stem cell heterogeneity and plasticity.
TL;DR: By understanding the interrelationship between CSCs and their differentiated progeny, the authors can hope to develop better therapeutic regimens that can prevent the emergence of tumor cell variants that are able to found a new tumor and distant metastases.
Journal ArticleDOI
NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation
Collene R. Jeter,Bigang Liu,Xin Liu,Xin Liu,Xin-Xin Chen,Can Liu,Tammy Calhoun-Davis,John Repass,Holm Zaehres,Jianjun Shen,Dean G. Tang +10 more
TL;DR: Gain-of-function studies establish the integral role for NANOG in neoplastic processes and shed light on its mechanisms of action in tumorigenesis, as well as establishing the importance of CXCR4, IGFBP5, CD133 and ALDH1 in this work.